CAS 76470-66-1

Loracarbef

Description:

Loracarbef is a synthetic antibiotic belonging to the class of beta-lactam antibiotics, specifically a carbapenem. It is primarily used to treat bacterial infections, particularly those caused by gram-positive and some gram-negative bacteria. Loracarbef works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The compound is characterized by its stability against certain beta-lactamases, which are enzymes produced by bacteria that can inactivate many other antibiotics. Loracarbef is typically administered orally and is known for its favorable pharmacokinetic properties, including good absorption and distribution in body tissues. It has a relatively low incidence of side effects, making it a suitable option for various infections. However, like all antibiotics, its use should be guided by susceptibility patterns to avoid the development of resistance. As with any medication, it is essential to consider potential interactions with other drugs and the patient's overall health status before prescribing Loracarbef.

Formula: C₁₆H₁₆ClN₃O₄

InChI: InChI=1S/C16H16ClN3O4/c17-9-6-7-10-12(15(22)20(10)13(9)16(23)24)19-14(21)11(18)8-4-2-1-3-5-8/h1-5,10-12H,6-7,18H2,(H,19,21)(H,23,24)/t10-,11-,12+/m1/s1

InChI key: InChIKey=JAPHQRWPEGVNBT-UTUOFQBUSA-N

SMILES: O=C1N2[C@@]([C@@H]1NC([C@H](N)C3=CC=CC=C3)=O)(CCC(Cl)=C2C(O)=O)[H]

Synonyms:

• Loracarbefum
• LY 163892
• Lorabid
• (6R,7S)-7-[[(2R)-2-Amino-2-phenylacetyl]amino]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R-(6alpha,7beta(R*)))-
• 1-Azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-aminophenylacetyl)amino)-3-chloro-8-oxo-, (6R,7S)-
• 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-chloro-8-oxo-, [6R-[6α,7β(R*)]]-
• UNII-W72I5ZT78Z
• Loracarbef [USAN:INN:BAN]
• KT 3777
• (6R,7S)-7-{[(2R)-2-amino-2-phenylacetyl]amino}-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• Loribid
• Loracarbefum [INN-Latin]
• 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-, (6R,7S)-
• 1-Azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-aminophenylacetyl]amino]-3-chloro-8-oxo-, (6R,7S)-

Loracarbef

CAS: 76470-66-1

Formula: C₁₆H₁₈ClN₃O₅

Molecular weight: 367.78

Ref: 7W-GP0853

Loracarbef monohydrate

CAS: 76470-66-1

Loracarbef monohydrate is a synthetic antibiotic, which is derived from carbacephem compounds with a mode of action that involves inhibiting bacterial cell wall synthesis. This is achieved by binding to penicillin-binding proteins, thereby blocking the cross-linking of peptidoglycan chains which are crucial for bacterial cell wall structural integrity.

Formula: C₁₆H₁₆ClN₃O₄·H₂O

Purity: Min. 95%

Molecular weight: 367.78 g/mol

Ref: 3D-FL24931