CAS 7648-98-8

Ambenonium

Description:

Ambenonium is a chemical compound primarily recognized as a reversible inhibitor of the enzyme acetylcholinesterase, which plays a crucial role in the breakdown of the neurotransmitter acetylcholine. This inhibition leads to increased levels of acetylcholine at neuromuscular junctions, enhancing neuromuscular transmission. Ambenonium is often used in the treatment of myasthenia gravis, a condition characterized by weakness in the skeletal muscles. The compound is typically administered in oral form and is known for its relatively long duration of action compared to other acetylcholinesterase inhibitors. In terms of its chemical properties, ambenonium is a quaternary ammonium compound, which contributes to its solubility in water and its ability to interact with biological systems. Safety and side effects should be monitored, as with any medication, due to potential cholinergic effects such as muscle cramps, increased salivation, and gastrointestinal disturbances. Overall, ambenonium serves as an important therapeutic agent in managing neuromuscular disorders.

Formula: C₂₈H₄₂Cl₂N₄O₂

InChI: InChI=1S/C28H40Cl2N4O2/c1-5-33(6-2,21-23-13-9-11-15-25(23)29)19-17-31-27(35)28(36)32-18-20-34(7-3,8-4)22-24-14-10-12-16-26(24)30/h9-16H,5-8,17-22H2,1-4H3/p+2

InChI key: InChIKey=OMHBPUNFVFNHJK-UHFFFAOYSA-P

SMILES: [N+](CC1=C(Cl)C=CC=C1)(CCNC(C(NCC[N+](CC2=C(Cl)C=CC=C2)(CC)CC)=O)=O)(CC)CC

Synonyms:

• [(2-Chlorophenyl)methyl](2-[[(2-[[(2-chlorophenyl)methyl]diethylazaniumyl]ethyl)carbamoyl]formamido]ethyl)diethylazanium
• Benzenemethanaminium, N,N′-[(1,2-dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethyl-
• Ambenonium
• N,N′-[(1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl)]bis[2-chloro-N,N-diethylbenzenemethanaminium]
• Ammonium, [oxalylbis(iminoethylene)]bis[(o-chlorobenzyl)diethyl-

Ambenonium

CAS: 7648-98-8

Ambenonium

Purity: ≥95%

Molecular weight: 537.57g/mol

Ref: 54-BUP20983

Ambenonium

CAS: 7648-98-8

Ambenonium (WIN 8077) is a competitive and reversible cholinesterase AChE inhibitor,orally available,for the treatment of myasthenia gravis.

Formula: C₂₈H₄₂Cl₂N₄O₂

Color and Shape: Solid

Molecular weight: 537.57

Ref: TM-T71758