H-Leu-Val-Tyr-AMC, also known as a peptide substrate, is a synthetic compound that consists of a sequence of amino acids: leucine (Leu), valine (Val), and tyrosine (Tyr), with an amide group (AMC) at the C-terminus. This compound is often utilized in biochemical assays, particularly for studying proteolytic enzymes, as it can be cleaved by specific proteases, releasing the AMC moiety, which fluoresces upon cleavage. The characteristics of H-Leu-Val-Tyr-AMC include its role as a substrate in enzyme kinetics studies, where its fluorescence can be quantitatively measured to assess enzyme activity. The compound is typically soluble in aqueous solutions, making it suitable for various biological applications. Its structure allows for specific interactions with enzymes, providing insights into enzyme specificity and activity. Additionally, the presence of aromatic amino acids like tyrosine contributes to its photophysical properties, enhancing its utility in fluorescence-based assays. Overall, H-Leu-Val-Tyr-AMC serves as a valuable tool in biochemical research and drug discovery.

H-Leu-Val-Tyr-AMC

76524-85-1: H-Leu-Val-Tyr-AMC, also known as a peptide substrate, is a synthetic compound that consists of a sequence of amino acids: leucine (Leu), valine (Val), and tyrosine (Tyr), with an amide group (AMC) at the C-terminus. This compound is often utilized in biochemical assays, particularly for studying proteolytic enzymes, as it can be cleaved by specific proteases, releasing the AMC moiety, which fluoresces upon cleavage. The characteristics of H-Leu-Val-Tyr-AMC include its role as a substrate in enzyme kinetics studies, where its fluorescence can be quantitatively measured to assess enzyme activity. The compound is typically soluble in aqueous solutions, making it suitable for various biological applications. Its structure allows for specific interactions with enzymes, providing insights into enzyme specificity and activity. Additionally, the presence of aromatic amino acids like tyrosine contributes to its photophysical properties, enhancing its utility in fluorescence-based assays. Overall, H-Leu-Val-Tyr-AMC serves as a valuable tool in biochemical research and drug discovery.

H-Leu-Val-Tyr-AMC is a model compound that belongs to the group of sulfonamides. It is synthesized and used as a chymotrypsin-like protease inhibitor. H-Leu-Val-Tyr-AMC has been shown to inhibit the activity of chymotrypsin, a serine protease, by binding to its active site. This inhibition leads to an increase in the time required for digestion of proteins and peptides, which may be due to the steric hindrance created by the bulky H-Leu-Val-Tyr. H-Leu-Val-Tyr amide also has antiinflammatory properties, which are thought to be caused by its ability to inhibit prostaglandin synthesis.

CAS 76524-85-1

H-Leu-Val-Tyr-AMC

H-Leu-Val-Tyr-AMC

Ref: 3D-FL110507