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CAS 765882-88-0

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De-1-((2-(2,4-dichlorophenyl)-1,3-dioxolan-2-yl)Methyl)-1H-1,2,4-triazole Itraconazole Sulfate

Description:
De-1-((2-(2,4-dichlorophenyl)-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole, commonly known as Itraconazole Sulfate, is an antifungal agent belonging to the triazole class. It exhibits a broad spectrum of activity against various fungal pathogens, including dermatophytes and yeasts. The compound functions by inhibiting the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting cell membrane integrity and function. Itraconazole is typically administered orally and is known for its favorable pharmacokinetic properties, including good absorption and extensive tissue distribution. The sulfate form enhances solubility and bioavailability. In terms of safety, it has a well-established profile, although potential side effects may include gastrointestinal disturbances and liver enzyme alterations. The compound is also subject to specific drug interactions, particularly with medications that affect hepatic metabolism. Overall, Itraconazole Sulfate is a vital therapeutic option in the management of systemic and superficial fungal infections.
Formula:C23H29N5O6S
Synonyms:
  • 1H-1,2,4-Triazol-5-one, 4,5-dihydro-4-[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]-1-[(1R,2R)-1-methyl-2-(sulfooxy)propyl]-, rel-
  • De-1-((2-(2,4-dichlorophenyl)-1,3-dioxolan-2-yl)Methyl)-1H-1,2,4-triazole Itraconazole Sulfate
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