CAS 76604-64-3

2(R)-[4-(3-Methyl-2-thienyl)phenyl]propionic acid

Description:

2(R)-[4-(3-Methyl-2-thienyl)phenyl]propionic acid, commonly known as a non-steroidal anti-inflammatory drug (NSAID), is characterized by its structural features that include a propionic acid moiety and a thienyl-substituted phenyl group. This compound exhibits anti-inflammatory, analgesic, and antipyretic properties, making it useful in the treatment of pain and inflammation. The presence of the thienyl group contributes to its unique pharmacological profile, potentially influencing its binding affinity to cyclooxygenase enzymes, which are pivotal in the inflammatory response. The stereochemistry of the molecule, indicated by the (R) configuration, is crucial for its biological activity, as enantiomers can exhibit different therapeutic effects and side effects. Additionally, this compound is typically soluble in organic solvents and may have limited solubility in water, which can affect its bioavailability. Safety and efficacy profiles are established through clinical studies, and like other NSAIDs, it may be associated with gastrointestinal and cardiovascular risks. Overall, this compound represents a significant class of therapeutic agents in pain management.

Formula: C₁₄H₁₄O₂S

InChI: InChI=1/C14H14O2S/c1-9-7-8-17-13(9)12-5-3-11(4-6-12)10(2)14(15)16/h3-8,10H,1-2H3,(H,15,16)/t10-/m1/s1

Synonyms:

• M-5011
• M-5010
• T-3788
• (2R)-2-[4-(3-methylthiophen-2-yl)phenyl]propanoic acid

M-5011

CAS: 76604-64-3

M-5011: NSAID and immunomodulator for pain and inflammation; ED50 0.63mg/kg; reduces bone loss in arthritis; low ulcer risk.

Formula: C₁₄H₁₄O₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 246.32

Ref: TM-T27968