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CAS 76630-71-2

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NALTREXONE-3-GLUCURONIDE

Description:
Naltrexone-3-glucuronide is a metabolite of naltrexone, an opioid antagonist used primarily in the treatment of opioid dependence and alcohol use disorder. This compound is formed through the conjugation of naltrexone with glucuronic acid, a process that enhances its solubility and facilitates excretion. Naltrexone-3-glucuronide is characterized by its chemical structure, which includes a glucuronide moiety attached to the naltrexone molecule, impacting its pharmacokinetics and pharmacodynamics. It is generally less active than naltrexone itself but can still exhibit some biological activity. The compound is typically analyzed in biological samples to monitor naltrexone metabolism and adherence to treatment regimens. Its presence can be detected using various analytical techniques, including liquid chromatography coupled with mass spectrometry. Understanding the characteristics of naltrexone-3-glucuronide is essential for evaluating the efficacy and safety of naltrexone therapy, as well as for research into opioid receptor interactions and metabolism.
Formula:C26H31NO10
Synonyms:
  • Naltrexone 3-O-β-D-Glucuronide (1.0 mg/ml in Methanol)
  • Naltrexone 3-O-β-D-Glucuronide
  • Naltrexone 3-O--D-Glucuronide
  • (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-14-hydroxy-6-oxomorphinan-3-yl -D-Glucopyranosiduronic Acid
  • (5α)-17-(CyclopropylMethyl)-4,5-epoxy-14-hydroxy-6-oxoMorphinan-3-yl β-D-Glucopyranosiduronic Acid
  • β-D-Glucopyranosiduronic acid, (5α)-17-(cyclopropylmethyl)-4,5-epoxy-14-hydroxy-6-oxomorphinan-3-yl
  • Naltrexone-3-β-D-glucuronide
  • (5a)-17-(Cyclopropylmethyl)-4,5-epoxy-14-hydroxy-6-oxomorphinan-3-yl b-D-Glucopyranosiduronic Acid
  • Naltrexone 3-O-b-D-Glucuronide
  • NALTREXONE-3-GLUCURONIDE
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