CAS 76684-89-4

Loxistatin acid

Description:

Loxistatin acid, with the CAS number 76684-89-4, is a chemical compound that belongs to the class of statins, which are primarily known for their role in cholesterol-lowering medications. It is characterized by its ability to inhibit HMG-CoA reductase, an enzyme crucial in the biosynthesis of cholesterol. This inhibition leads to a decrease in cholesterol levels in the bloodstream, making it beneficial for managing hyperlipidemia and reducing the risk of cardiovascular diseases. Loxistatin acid is typically a white to off-white solid and is soluble in organic solvents, but its solubility in water is limited. The compound may exhibit various biological activities, including anti-inflammatory and antioxidant properties, which contribute to its therapeutic potential. As with many statins, it may have side effects, including muscle pain and liver enzyme alterations, necessitating monitoring during use. Overall, Loxistatin acid represents a significant advancement in pharmacology for cardiovascular health management.

Formula: C₁₅H₂₆N₂O₅

InChI: InChI=1/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1

InChI key: InChIKey=SCMSYZJDIQPSDI-SRVKXCTJSA-N

SMILES: C(N[C@H](C(NCCC(C)C)=O)CC(C)C)(=O)[C@@H]1[C@@H](C(O)=O)O1

Synonyms:

• (+)-(2S,3S)-3-((S)-3-Methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylic acid
• (2S,3S)-3-({(2S)-4-methyl-1-[(3-methylbutyl)amino]-1-oxopentan-2-yl}carbamoyl)oxirane-2-carboxylic acid
• (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic acid
• 2-Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, (2S,3S)-
• Brn 6688621
• E 64c
• EP 475 (Enzyme inhibitor)
• Ep 475
• Loxistatin acid
• NSC 694279
• Oxiranecarboxylic acid, 3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)amino)carbonyl)-, (2S-(2-alpha,3-beta(R*)))-
• Oxiranecarboxylic acid, 3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)amino)carbonyl)-, (2S-(2alpha,3beta(R*)))-
• Oxiranecarboxylic acid, 3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, (2S,3S)-
• Oxiranecarboxylic acid, 3-[[[3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-, [2S-[2α,3β(R*)]]-
• (2S,3S)-L-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE
• (1S,2S)-2-(((S)-1-(Isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)cyclopropanecarboxylic
• anecarboxylicacid
• (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-3-METHYLBUTANE
• Loxistatin Acid (E-64C)
• (2S,3S)-3-(((S)-1-(isopentylaMino)-4-Methyl-1-oxopentan-2-yl)carbaMoyl)oxirane-2-carboxylic acid
• E-64-c Loxistatin acid NSC 694279
• (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCINE (3-METHYLBUTYL)AMIDE
• (2S,3S)-3-[[(1S)-1-(3-Methylbutylcarbamoyl)-3-methylbutyl]carbamoyl]oxirane-2-carboxylic acid
• NSC 694279 Loxistatin Acid
• NSC 694279 LOXISTATIN ACID; EP 475;E64C;E 64C
• (2s-(2-alpha,3-beta(r*)))-mino)carbonyl)
• ep475(enzymeinhibitor)
• L-TRANS-EPOXYSUCCINYL-LEU-3-METHYLBUTYLAMIDE
• (+)-(2s,3s)-3-((s)-3-methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxir
• (2S,3S)-TRANS-EPOXYSUCCINYL-L-*LEUCYLAMI DO-3-METHYL
• oxiranecarboxylicacid,3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)a
• Inhibitorforthiolprotease
• 2-Oxiranecarboxylicacid,3-[[[(1S)-3-methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-,(2S,3S)-
• E-64c, EP 475

E-64c

CAS: 76684-89-4

Formula: C₁₅H₂₆N₂O₅

Purity: 95%

Color and Shape: Solid

Molecular weight: 314.3773

Ref: IN-DA00G359

E 64c

CAS: 76684-89-4

E 64c

Purity: ≥98%

Molecular weight: 314.38g/mol

Ref: 54-BUP02992

E-64c Calpain Inhibitor

CAS: 76684-89-4

Formula: C₁₅H₂₆N₂O₅

Molecular weight: 314.38

Ref: 7W-GL8757

E-64c

CAS: 76684-89-4

E-64c

Purity: 95%

Color and Shape: Solid

Molecular weight: 314.38g/mol

Ref: 54-BIE1004

E 64c

CAS: 76684-89-4

E 64c (EP 475) , a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor.

Formula: C₁₅H₂₆N₂O₅

Purity: 98.73%

Color and Shape: Solid

Molecular weight: 314.38

Ref: TM-T6573

(2S,3S)-3-(((S)-1-(Isopentylamino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid

CAS: 76684-89-4

Purity: ≥98%

Molecular weight: 314.3819885

Ref: 10-F869543

E-64-c

CAS: 76684-89-4

E-64-c is a research tool that is used to activate the receptor of a cell. This ligand can bind to the receptor and form a complex, which will then be able to interact with other proteins in the cell. This process can lead to changes in ion channel activity, protein synthesis, or gene expression. E-64-c has been shown to inhibit the activity of ion channels such as calcium channels and potassium channels, as well as protein synthesis. It also binds to antibodies and blocks their binding sites on cells.br>
E-64-c is a high purity ligand that can be used for studying protein interactions or pharmacological purposes. The potency of this ligand has been tested by measuring its ability to inhibit the binding of various peptides such as vasopressin and angiotensin II.

Formula: C₁₅H₂₆N₂O₅

Purity: Min. 95%

Molecular weight: 314.38 g/mol

Ref: 3D-IEC-4320-V