CAS 76712-82-8

des-gly10,(D-his(bzl)6)-lh-rh*ethylamide

Description:

Des-gly10,(D-his(bzl)6)-lh-rh*ethylamide, with the CAS number 76712-82-8, is a synthetic peptide analog derived from the naturally occurring hormone luteinizing hormone-releasing hormone (LHRH). This compound is characterized by its structural modifications, which include the deletion of the glycine residue at position 10 and the incorporation of a D-histidine residue with a benzyl group at position 6. These modifications enhance its stability and bioactivity compared to the native LHRH. The compound typically exhibits high affinity for LHRH receptors, making it of interest in research related to reproductive biology and potential therapeutic applications in hormone-related disorders. Its unique structure allows for prolonged action in biological systems, which can be beneficial in clinical settings. As a peptide, it is generally soluble in aqueous solutions and may require specific conditions for storage and handling to maintain its integrity. Overall, des-gly10,(D-his(bzl)6)-lh-rh*ethylamide represents a significant advancement in peptide design for targeted hormonal therapies.

Formula: C₆₆H₈₆N₁₈O₁₂

InChI: InChI=1/C66H86N18O12.C2H4O2/c1-4-70-64(95)55-17-11-25-84(55)65(96)48(16-10-24-71-66(67)68)76-58(89)49(26-38(2)3)77-62(93)53(30-43-34-83(37-74-43)33-40-12-6-5-7-13-40)81-59(90)50(27-39-18-20-44(86)21-19-39)78-63(94)54(35-85)82-60(91)51(28-41-31-72-46-15-9-8-14-45(41)46)79-61(92)52(29-42-32-69-36-73-42)80-57(88)47-22-23-56(87)75-47;1-2(3)4/h5-9,12-15,18-21,31-32,34,36-38,47-55,72,85-86H,4,10-11,16-17,22-30,33,35H2,1-3H3,(H,69,73)(H,70,95)(H,75,87)(H,76,89)(H,77,93)(H,78,94)(H,79,92)(H,80,88)(H,81,90)(H,82,91)(H4,67,68,71);1H3,(H,3,4)/t47-,48-,49-,50-,51-,52-,53+,54-,55-;/m0./s1

Synonyms:

• Histrelin
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide
• 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-1-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-prolinamide acetate (1:1)
• ^-benzyl-D-histidyl-L-leucyl-L-arginyl-N-ethyl-L-pmlinamide
• 6-(1-(phenylmethyl)-d-histidine)-9-luteinizinghormonereleasingfactor(pig
• (n-ethyl-l-prolinamide)-10-deglycinamide-
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-GONADOTROPIN-RELEASING HORMONE
• Supprelin
• Histreline Acetate
• histrelin acetate
• 1-9-LUTEINIZING HORMONE-RELEASING FACTOR (SWINE), 6-[1-(PHENYLMETHYL)-D-HISTIDINE]-9-(N-ETHYL-L-PROLINAMIDE)-
• 5-Oxo-L-Pro-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-N-ethyl-NH2
• RWJ-17070
• DES-GLY10,[D-HIS(BZL)6]-LH-RH ETHYLAMIDE
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
• ((imbl)-d-his(sub6),pro(sub9)-net)lhrh
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PYR-HIS-TRP-SER-TYR-D-HIS(BZL)-LEU-ARG-PRO-NHET
• orf17070
• (HIS(BZL)6)-HISTRELIN
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LHRH
• Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• 5-oxo-L-pmlyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-N^
• [DES-GLY10, D-HIS(BZL)6, PRO-NHET9]-LH-RH (HUMAN)
• (DES-GLY10,D-HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING FACTOR
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LHRH
• PYR-HIS-TRP-SER-TYR-HIS(BZL)-LEU-ARG-PRO-NHET
• (DES-GLY10,HIS(BZL)6,PRO-NHET9)-LUTEINIZING HORMONE-RELEASING HORMONE
• PGLU-HIS-TRP-SER-TYR-D-HIS[BZL]-LEU-ARG-PRO-NHET

Histrelin

CAS: 76712-82-8

Formula: C₆₆H₈₆N₁₈O₁₂

Molecular weight: 1323.50

Ref: 7W-GP6870

Histrelin

CAS: 76712-82-8

Formula: C₆₆H₈₆N₁₈O₁₂

Molecular weight: 1323.53

Ref: 4Z-PH-047001

Histrelin Acetate

CAS: 76712-82-8

Formula: C₆₆H₈₆N₁₈O₁₂

Purity: 95%~99%

Color and Shape: White to Off-white Powder

Molecular weight: 1323.5

Ref: BP-BPPG040

Histrelin Acetic Acid Salt

CAS: 76712-82-8

Applications Histrelin is a gonadotropin releasing hormone analog used with the potential to improve height prospects.
References Brauner, R. et al.: Nat. Rev. Endocrinol., 11, 386 (2015);

Formula: C₆₆H₈₆N₁₈O₁₂•xCH₃COOH

Color and Shape: Neat

Molecular weight: 1323.506005

Ref: TR-H456310

Histrelin Acetate

CAS: 76712-82-8

Histrelin acetate is a synthetic analog of the natural hormone histrelin. It has been used clinically to treat prostate cancer, androgenetic alopecia, and other conditions. Histrelin acetate binds to receptors in the hypothalamus and pituitary gland that are responsible for regulating the production of sex hormones. This drug is administered by injection into the pubic area or under the skin as an implant. Histrelin acetate's effectiveness is related to its suppression of gonadotropins, which results in decreased testosterone levels. Histrelin acetate also decreases testosterone production by inhibiting gonadotropin-releasing hormone from stimulating the anterior pituitary gland to produce luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The long-term efficacy of this drug has been demonstrated in clinical studies lasting up to two years with no significant adverse effects on bone mineral density or sexual function.

Purity: Min. 95%

Ref: 3D-FH138112