CAS 76721-89-6

Thiorphan

Description:

Thiorphan, with the CAS number 76721-89-6, is a potent and selective inhibitor of the enzyme neprilysin, which plays a crucial role in the degradation of various neuropeptides and peptides involved in pain modulation and cardiovascular regulation. This compound is characterized by its ability to enhance the levels of endogenous peptides, thereby influencing physiological processes such as pain perception and blood pressure regulation. Thiorphan is typically presented as a white to off-white solid and is soluble in water and organic solvents, making it versatile for various applications in biochemical research. Its mechanism of action involves the inhibition of neprilysin, leading to increased concentrations of peptides like enkephalins and substance P. Due to its pharmacological properties, thiorphan has been studied for potential therapeutic applications in conditions such as hypertension and pain management. However, its use in clinical settings is limited, and further research is needed to fully understand its effects and potential side effects.

Formula: C₁₂H₁₅NO₃S

InChI: InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)

InChI key: InChIKey=LJJKNPQAGWVLDQ-UHFFFAOYSA-N

SMILES: C(C(C(NCC(O)=O)=O)CS)C1=CC=CC=C1

Synonyms:

• Glycine, N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-, (±)-
• Thiorphan
• Glycine, N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-
• (±)-Thiorphan
• N-[2-(Mercaptomethyl)-1-oxo-3-phenylpropyl]glycine

DL-Thiorphan

CAS: 76721-89-6

Thiorphan has the ability to block the degradation of the luteinizing hormone releasing hormone (LHRH). At higher concentrations, (14 ?M) this compound has been shown to inhibit the activity of angiotensin-converting enzyme (ACE). Neprilysin is overexpressed in many forms of cancer and may play a ro

Formula: C₁₂H₁₅NOS

Molecular weight: 253.32

Ref: 02-J62557

DL-Thiorphan

CAS: 76721-89-6

Potent and specific inhibitor of neprilysin with antinociceptive activity. Thiorphan is cleaved by peptidylglycine α-amidating monooxygenase yielding 2-benzyl-3-mercaptopropionamide.

Formula: C₁₂H₁₅NO₃S

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 253.32

Ref: 01-4010438

2-[(2-benzyl-3-sulfanylpropanoyl)amino]acetic acid

CAS: 76721-89-6

Formula: C₁₂H₁₅NO₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 253.3174

Ref: IN-DA0035P3

Thiorphan

CAS: 76721-89-6

Thiorphan

Purity: ≥98%

Molecular weight: 253.32g/mol

Ref: 54-BUP09710

Thiorphan-d5

CAS: 76721-89-6

Formula: C₁₂H₁₀D₅NO₃S

Color and Shape: White To Off-White Solid

Molecular weight: 258.35

Ref: 4Z-T-472

DL-Thiorphan

CAS: 76721-89-6

Formula: C₁₂H₁₅NOS

Purity: ≥ 97.0%

Color and Shape: White or almost white powder

Molecular weight: 253.32

Ref: 7W-GL2922

Thiorphan

CAS: 76721-89-6

Formula: C₁₂H₁₅NO₃S

Color and Shape: White To Off-White Solid

Molecular weight: 253.32

Ref: 4Z-T-471

Thiorphan

CAS: 76721-89-6

Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).

Formula: C₁₂H₁₅NO₃S

Purity: 99.33%

Color and Shape: Off-White Solid

Molecular weight: 253.32

Ref: TM-T7693

Thiorphan

Controlled Product

CAS: 76721-89-6

Formula: C₁₂H₁₅NO₃S

Color and Shape: Neat

Molecular weight: 253.32

Ref: TR-T369500

Thiorphan

CAS: 76721-89-6

Thiorphan is a drug that was originally developed as an experimental anti-inflammatory agent. It is also used as a research tool to study the pulmonary hypertension in experimental models. Thiorphan has been shown to inhibit the polymerase chain reaction (PCR) of DNA, which may be due to its ability to bind and inhibit the activity of enzymes such as picolinic acid hydrolase and carboxypeptidase A2. This drug has been shown to have no effect on locomotor activity or atrial contractility, but does cause neuronal death in the caudate putamen. Thiorphan has also been shown to be an inhibitor of phosphodiesterases, which are enzymes that break down intracellular messenger chemicals called cyclic adenosine monophosphate (cAMP).

Formula: C₁₂H₁₅NO₃S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 253.32 g/mol

Ref: 3D-FT28239

DL-THIORPHAN

CAS: 76721-89-6

Formula: C₁₂H₁₅NO₃S

Purity: 98%

Molecular weight: 253.32

Ref: 10-F475389

Thiorphan-d5

Controlled Product

CAS: 76721-89-6

Formula: C₁₂D₅H₁₀NO₃S

Color and Shape: Neat

Molecular weight: 258.348

Ref: TR-T369503

S-[2-(2-Bromo-3-methoxyphenyl)-2-oxoethyl] Thiorphan Dicyclohexylamine Salt

Controlled Product

CAS: 76721-89-6

Formula: C₂₁H₂₂BrNO₅S·C₁₂H₂₃N

Color and Shape: Neat

Molecular weight: 661.69

Ref: TR-B683875

Racecadotril EP Imurity B

CAS: 76721-89-6

Formula: C₁₂H₁₅NO₃S

Molecular weight: 253.32

Ref: ST-EA-CP-R21002