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CAS 76752-41-5

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(3beta)-25-fluorocholest-5-ene-3,22-diol

Description:
(3beta)-25-fluorocholest-5-ene-3,22-diol, with CAS number 76752-41-5, is a synthetic derivative of cholesterol, characterized by the presence of a fluorine atom at the 25-position and hydroxyl groups at the 3 and 22 positions. This compound belongs to the class of sterols, which are vital components of cell membranes and precursors to various biological molecules. The fluorine substitution can influence the compound's biological activity, potentially enhancing its stability and altering its interaction with biological targets. The presence of hydroxyl groups contributes to its polarity, affecting solubility and reactivity. Such modifications can impact the compound's pharmacological properties, making it of interest in medicinal chemistry and drug development. Additionally, the structural configuration, particularly the stereochemistry at the 3beta position, plays a crucial role in determining its biological function and interaction with enzymes or receptors. Overall, (3beta)-25-fluorocholest-5-ene-3,22-diol represents a significant modification of the cholesterol framework, with potential applications in therapeutic contexts.
Formula:C27H45FO2
InChI:InChI=1/C27H45FO2/c1-17(24(30)12-13-25(2,3)28)21-8-9-22-20-7-6-18-16-19(29)10-14-26(18,4)23(20)11-15-27(21,22)5/h6,17,19-24,29-30H,7-16H2,1-5H3/t17-,19-,20-,21+,22-,23-,24?,26-,27+/m0/s1
Synonyms:
  • Cholest-5-Ene-3,22-Diol, 25-Fluoro-, (3Beta)-
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Found 1 products.
  • 22-Hydroxy-25-Fluorocholesterol
    Biosynth
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    22-Hydroxy-25-Fluorocholesterol

    Controlled Product
    CAS:
    <p>22-Hydroxy-25-fluorocholesterol is a cholesterol acyltransferase inhibitor, which prevents the synthesis of cholesterol in the body. It is also used as a sequestering agent, preventing cholesterol from being absorbed into the body. This drug has been shown to decrease high cholesterol levels and oxysterols in patients with coronary artery disease. 22-Hydoxy-25-fluorocholesterol binds to cellular membranes and blocks the transport of bile acids and acid, thereby inhibiting cholesterol synthesis. It also inhibits inflammation by blocking inflammatory cytokines such as TNF-α and IL-1β. This drug may also be useful for treating inflammatory diseases such as asthma and rheumatoid arthritis due to its inhibition of leukotriene synthesis.</p>
    Formula:C27H45FO2
    Purity:Min. 95%
    Molecular weight:420.64 g/mol

    Ref: 3D-FH80031

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