Trimethylsilyl cyanide (TMSCN) is a chemical compound characterized by its structure, which includes a cyanide group (-C≡N) bonded to a trimethylsilyl group (Si(CH₃)₃). It is a colorless to pale yellow liquid with a faint odor, and it is known for its volatility and low boiling point. TMSCN is soluble in organic solvents such as ether and acetone but is less soluble in water due to the hydrophobic nature of the trimethylsilyl group. This compound is primarily used as a reagent in organic synthesis, particularly in the formation of carbon-nitrogen bonds and as a protecting group for alcohols and amines. It is also utilized in the synthesis of various organic compounds, including nitriles and amines. However, TMSCN is toxic and should be handled with care, as it can release toxic cyanide gas upon hydrolysis. Proper safety precautions, including the use of personal protective equipment and working in a well-ventilated area or fume hood, are essential when working with this substance.

Trimethylsilyl cyanide

7677-24-9: Trimethylsilyl cyanide (TMSCN) is a chemical compound characterized by its structure, which includes a cyanide group (-C≡N) bonded to a trimethylsilyl group (Si(CH₃)₃). It is a colorless to pale yellow liquid with a faint odor, and it is known for its volatility and low boiling point. TMSCN is soluble in organic solvents such as ether and acetone but is less soluble in water due to the hydrophobic nature of the trimethylsilyl group. This compound is primarily used as a reagent in organic synthesis, particularly in the formation of carbon-nitrogen bonds and as a protecting group for alcohols and amines. It is also utilized in the synthesis of various organic compounds, including nitriles and amines. However, TMSCN is toxic and should be handled with care, as it can release toxic cyanide gas upon hydrolysis. Proper safety precautions, including the use of personal protective equipment and working in a well-ventilated area or fume hood, are essential when working with this substance.

<p>Trimethylsilyl Cyanide is used as a reagent in the preparation of optically active cyanohydrins. It is used in the derivatization of complex metabolite mixtures by GC-MS. It is employed in the preparation of Reissert compounds, which represent reactive polyamides. Further, it is used to convert pyri</p>

CAS 7677-24-9

Trimethylsilyl cyanide

Trimethylsilyl cyanide, 97%

Ref: 02-A19598