CAS 768-60-5

1-Ethynyl-4-methoxybenzene

Description:

1-Ethynyl-4-methoxybenzene, also known as p-ethynyl anisole, is an organic compound characterized by the presence of an ethynyl group (-C≡CH) attached to a methoxy-substituted benzene ring. Its molecular formula is C10H10O, indicating it contains ten carbon atoms, ten hydrogen atoms, and one oxygen atom. This compound typically appears as a colorless to pale yellow liquid with a distinct aromatic odor. It is known for its applications in organic synthesis, particularly in the production of various pharmaceuticals and agrochemicals. The presence of the ethynyl group enhances its reactivity, making it a useful intermediate in coupling reactions, such as Sonogashira reactions, which are pivotal in forming carbon-carbon bonds. Additionally, 1-ethynyl-4-methoxybenzene exhibits moderate solubility in organic solvents, while its stability can be influenced by factors such as temperature and exposure to light. As with many organic compounds, proper handling and safety precautions are essential due to potential health hazards associated with exposure.

Formula: C₉H₈O

InChI: InChI=1S/C9H8O/c1-3-8-4-6-9(10-2)7-5-8/h1,4-7H,2H3

InChI key: InChIKey=KBIAVTUACPKPFJ-UHFFFAOYSA-N

SMILES: C(#C)C1=CC=C(OC)C=C1

Synonyms:

• (4-Methoxyphenyl)acetylene
• (p-Methoxyphenyl)acetylene
• 1-Eth-1-ynyl-4-methoxybenzene
• 1-Methoxy-4-ethynylbenzene
• 2-(4-Methoxyphenyl)acetylene
• 4-Ethynyl-1-methoxybenzene
• 4-Ethynylanisole
• 4-Methoxy-1-ethynylbenzene
• 4-Methoxyphenylacetylene
• 4-Methoxyphenylethyne
• Anisole, p-ethynyl-
• Anisylacetylene
• Benzene, 1-ethynyl-4-methoxy-
• NSC 71091
• p-Anisylacetylene
• p-Anisylethyne
• p-Ethynylanisole
• p-Methoxyethynylbenzene
• p-Methoxylphenylacetylene
• p-Methoxyphenylethyne

4-Methoxyphenylacetylene, 98%

CAS: 768-60-5

4-Ethynylanisole was used in the synthesis of photo luminescent 1,2-dihydrophosphinines via a [4 + 2] cycloaddition. Along with an arylboronic acid and sodium azide in a copper-catalyzed, three-component synthesis of trisubstituted 1,2,4-triazoles. In a study of a gold (III)-catalyzed hydroamination

Formula: C₉H₈O

Purity: 98%

Color and Shape: Liquid, Clear colorless to yellow

Molecular weight: 132.16

Ref: 02-H26283

4-Ethynylanisole

CAS: 768-60-5

Formula: C₉H₈O

Purity: 96%

Color and Shape: Solid

Molecular weight: 132.1592

Ref: IN-DA003LCL

4-Methoxyphenylacetylene

CAS: 768-60-5

4-Methoxyphenylacetylene

Formula: C₉H₈O

Purity: 98%

Color and Shape: yellow solid

Molecular weight: 132.16g/mol

Ref: 54-OR21951

4-Ethynylanisole

CAS: 768-60-5

Formula: C₉H₈O

Purity: >98.0%(GC)

Color and Shape: White to Orange to Green powder to lump

Molecular weight: 132.16

Ref: 3B-E0603

4-Methoxyphenylacetylene

Controlled Product

CAS: 768-60-5

Formula: C₉H₈O

Color and Shape: Neat

Molecular weight: 132.16

Ref: TR-M265805

4′-Methoxyphenyl acetylene

CAS: 768-60-5

Formula: C₉H₈O

Purity: 98.0%

Color and Shape: Solid, Low Melting Solid

Molecular weight: 132.162

Ref: 10-F040076

4-Methoxyphenylacetylene

CAS: 768-60-5

4-Methoxyphenylacetylene is a phosphane that has been extensively studied for its reactivity in cross-coupling reactions with electron-deficient olefins. 4-Methoxyphenylacetylene has been shown to react with chlorides and form an intermediate chloride, which reacts with an olefin to form an ether. X-ray crystal structures of the reaction mechanism have been determined. The transfer mechanism involves nucleophilic attack of chloride on the phosphorus atom followed by elimination of hydrogen chloride from the phosphorus. The reaction product is an ether.

Formula: C₉H₈O

Purity: Min. 95%

Color and Shape: White Clear Liquid

Molecular weight: 132.16 g/mol

Ref: 3D-FM25339