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CAS 7681-54-1

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Indomethacin sodium

Description:
Indomethacin sodium is a non-steroidal anti-inflammatory drug (NSAID) primarily used to relieve pain, swelling, and inflammation. It is the sodium salt form of indomethacin, which enhances its solubility and bioavailability. The compound typically appears as a white to off-white crystalline powder and is soluble in water, making it suitable for intravenous administration. Indomethacin sodium functions by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of inflammation and pain. It is commonly prescribed for conditions such as arthritis, bursitis, and tendinitis. While effective, indomethacin sodium can have side effects, including gastrointestinal issues, cardiovascular risks, and renal impairment, necessitating careful monitoring during use. Its pharmacokinetics involve rapid absorption and distribution, with a half-life that allows for effective dosing regimens. As with all medications, it is essential to use indomethacin sodium under medical supervision to mitigate potential adverse effects and interactions with other drugs.
Formula:C19H16ClNO4·Na
InChI:InChI=1S/C19H16ClNO4.Na/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;/h3-9H,10H2,1-2H3,(H,22,23);
InChI key:InChIKey=FGHJWZIYJTXFEK-UHFFFAOYSA-N
SMILES:C(=O)(N1C=2C(C(CC(O)=O)=C1C)=CC(OC)=CC2)C3=CC=C(Cl)C=C3.[Na]
Synonyms:
  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt
  • 1H-indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt (1:1)
  • Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt
  • Indomethacin Sodium
  • Indomethacin sodium salt
  • Osmosin
  • Sodium indomethacin
  • sodium [1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetate
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