CAS 7683-36-5

Obidoxime

Description:

Obidoxime is a chemical compound classified as an oxime and is primarily known for its role as a reactivator of acetylcholinesterase, an enzyme inhibited by organophosphate and carbamate pesticides. It is often used in medical settings as an antidote for poisoning by these substances. Obidoxime has a molecular formula that includes a hydroxylamine functional group, which contributes to its reactivity. The compound is typically administered in its chloride salt form, enhancing its solubility in water. Obidoxime exhibits a relatively low toxicity profile when used appropriately, but it can cause side effects such as muscle twitching or gastrointestinal disturbances. Its mechanism of action involves the nucleophilic attack on the phosphorylated enzyme, leading to the restoration of its activity. The compound is usually administered via injection, and its effectiveness can be influenced by the timing of administration relative to exposure to the toxic agent. Overall, Obidoxime is a crucial therapeutic agent in the management of certain types of poisoning, highlighting its importance in toxicology and emergency medicine.

Formula: C₁₄H₁₆N₄O₃

InChI: InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2

InChI key: InChIKey=HIGRLDNHDGYWQJ-UHFFFAOYSA-P

SMILES: C(OC[N+]=1C=CC(C=NO)=CC1)[N+]=2C=CC(C=NO)=CC2

Synonyms:

• 1,1′-[Oxybis(methylene)]bis[4-[(hydroxyimino)methyl]pyridinium]
• Pyridinium, 1,1′-[oxybis(methylene)]bis[4-[(hydroxyimino)methyl]-
• Obidoxime