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CAS 76862-65-2

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conotoxin gi

Description:
Conotoxin Gi is a peptide toxin derived from the venom of certain cone snails, specifically from the species Conus geographus. It is classified as a conotoxin, which are small, disulfide-rich peptides that target various ion channels and receptors in the nervous system. Conotoxin Gi primarily acts as a selective inhibitor of the N-type voltage-gated calcium channels (Cav2.2), which play a crucial role in neurotransmitter release and pain signaling. This inhibition can lead to analgesic effects, making conotoxins of interest for pain management research. The structure of conotoxin Gi includes multiple disulfide bonds that contribute to its stability and biological activity. Due to its specificity and potency, conotoxin Gi is studied for potential therapeutic applications, particularly in the development of novel analgesics. However, its use is limited by the challenges associated with peptide drug delivery and potential side effects. Overall, conotoxin Gi exemplifies the complex interplay between natural products and pharmacology, highlighting the potential of venom-derived compounds in drug discovery.
Formula:C55H80N20O18S4
InChI:InChI=1/C55H80N20O18S4/c1-25-44(83)72-36-21-95-97-22-37(73-45(84)29(56)9-10-42(80)81)52(91)74-38(51(90)69-33(16-40(57)78)54(93)75-12-4-8-39(75)53(92)65-25)23-96-94-20-35(43(58)82)71-50(89)34(19-76)70-48(87)31(14-26-5-2-6-28(77)13-26)67-49(88)32(15-27-17-61-24-64-27)68-47(86)30(7-3-11-62-55(59)60)66-41(79)18-63-46(36)85/h2,5-6,13,17,24-25,29-39,76-77H,3-4,7-12,14-16,18-23,56H2,1H3,(H2,57,78)(H2,58,82)(H,61,64)(H,63,85)(H,65,92)(H,66,79)(H,67,88)(H,68,86)(H,69,90)(H,70,87)(H,71,89)(H,72,83)(H,73,84)(H,74,91)(H,80,81)(H4,59,60,62)/t25-,29-,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
SMILES:C[C@H]1C(=N[C@H]2CSSC[C@@H](C(=N[C@@H](CSSC[C@@H](C(=N)O)N=C([C@H](CO)N=C([C@H](Cc3cccc(c3)O)N=C([C@H](Cc3cnc[nH]3)N=C([C@H](CCCNC(=N)N)N=C(CN=C2O)O)O)O)O)O)C(=N[C@@H](CC(=N)O)C(=O)N2CCC[C@H]2C(=N1)O)O)O)N=C([C@H](CCC(=O)O)N)O)O
Synonyms:
  • a-Conotoxin GI, Conus geographus
  • H-Glu-Cys-Cys-Asn-Pro-Ala-Cys-Gly-Arg-His-Tyr-Ser-Cys-NH2 (Disulfide bonds between Cys2 and Cys7/Cys3 and Cys13)
  • Alpha-Conotoxin Gi
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Found 3 products.
  • α-conotoxin-GI
    Biosynth
    + Info

    α-conotoxin-GI

    CAS:
    α/δ site of the muscle-type nAChR blocker

    Ref: 3D-PP51208

    500µg
    324.00€
  • Alpha-Conotoxin GI
    Biosynth
    + Info

    Alpha-Conotoxin GI

    CAS:
    <p>A synthetic cone snail toxin, sourced from the marine snail, Conus geographus and can be applied as a blocker for the nicotinic acetylcholine receptor. This product is available as a 0.5mg vial with disulfide bonds between Cys2-Cys7 and Cys3-Cys13 and in the hydrochloride salt form.</p>
    Formula:C55H80N20O18S4
    Purity:Min. 95%
    Molecular weight:1,437.6 g/mol

    Ref: 3D-PCN-4126-V

    500µg
    1,005.00€
  • α-Conotoxin GI
    Targetmol
    + Info

    α-Conotoxin GI

    CAS:
    <p>α-conotoxin GI, a conopeptide isolated from the venom of the cone snail Conus geographus, is a competitive antagonist of the muscle-type nicotinic acetylcholine</p>
    Formula:C55H80N20O18S4
    Purity:98%
    Color and Shape:Solid
    Molecular weight:1437.61

    Ref: TM-T35325

    25mg
    Discontinued
    Discontinued product