CAS 76877-33-3

1-{4-[7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl]phenyl}-1H-pyrrole-2,5-dione

Description:

1-{4-[7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl]phenyl}-1H-pyrrole-2,5-dione, with CAS number 76877-33-3, is a synthetic organic compound characterized by its complex structure that includes a pyrrole ring and a chromenone moiety. This compound typically exhibits properties associated with both chromophores and heterocycles, making it of interest in various fields such as organic synthesis and medicinal chemistry. The presence of the diethylamino group suggests potential applications in dye chemistry or as a fluorescent probe due to its ability to influence electronic properties and solubility. Additionally, the compound may display biological activity, which could be explored for pharmaceutical applications. Its stability, solubility, and reactivity would depend on the specific conditions and solvents used, as well as the presence of functional groups that can participate in chemical reactions. Overall, this compound represents a versatile structure with potential applications in both research and industry.

Formula: C₂₄H₂₂N₂O₄

InChI: InChI=1/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

SMILES: CCN(CC)c1ccc2c(C)c(c3ccc(cc3)N3C(=O)C=CC3=O)c(=O)oc2c1

Synonyms:

• 3-(4-Maleimidophenyl)-4-methyl-7-(diethylamino)coumarin

1-[4-[7-(diethylamino)-4-methyl-2-oxochromen-3-yl]phenyl]pyrrole-2,5-dione

CAS: 76877-33-3

Formula: C₂₄H₂₂N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 402.4425

Ref: IN-DA00ICS2

CPM

CAS: 76877-33-3

CPM

Purity: ≥95%

Molecular weight: 402.44g/mol

Ref: 54-OR1034293

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

CAS: 76877-33-3

Formula: C₂₄H₂₂N₂O₄

Purity: ≥ 95.0%

Color and Shape: Pale yellow to yellow or orange powder or solid

Molecular weight: 402.44

Ref: 7W-GT9922

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

Controlled Product

CAS: 76877-33-3

Applications 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin is a thiol-reactive fluorescent probe. 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM) is a thiol-reactive fluorescent probe. CPM selectively forms Michael adducts in the presence of hyperreactive sulfhydryls. CPM has been used to monitor the release of thiols, quantitate thiol in microplate reactions, and to distinguish proliferating cancer cells by nucleolar protein staining. Dyes and metabolites.
References 1. Sippel, T.O. 1981. J. Histochem. Cytochem. 29: 1377-1381. PMID: 73204962. Liu, G., et al. 1994. J. Biol. Chem. 269: 33028-33034. PMID: 78065313. Liu, G., et al. 1994. Mol. Pharmacol. 45: 189-200. PMID: 81146704. Feng, W., et al. 1999. Mol. Pharmacol. 55: 821-831. PMID: 102205605. Han, M.S., et al. 2004. J. Org. Chem. 69: 2853-2855. PMID: 150749386. Ptak, C.P., et al. 2005. Biochemistry. 44: 62-71. PMID: 156288467. Khersonsky, O., et al. 2006. Chembiochem. 7: 49-53. PMID: 16329153

Formula: C₂₄H₂₂N₂O₄

Color and Shape: Neat

Molecular weight: 402.44

Ref: TR-D473778

7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin

CAS: 76877-33-3

7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin is a fluorescent probe that can be used to measure the cytosolic calcium concentration. This probe binds to heparin, which is a positive ionic charge and has been shown to cause an increase in cytosolic calcium levels in cultured cells. 7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin has been used to successfully monitor changes in cytosolic calcium levels in response to pharmacological agents, such as the monoclonal antibody TNF-α. 7-Diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin has also been used as a marker for tissue culture studies, where it was found that this molecule binds to the ryanodine receptor and alters its redox potential.

Formula: C₂₄H₂₂N₂O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 402.44 g/mol

Ref: 3D-FD36317

CPM

CAS: 76877-33-3

Purity: 98%

Molecular weight: 402.16

Ref: 10-F567294