CAS 7688-64-4
:O-acetylcamptothecin
Description:
O-acetylcamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. This substance is characterized by its unique structure, which includes a lactone ring that is crucial for its biological activity. O-acetylcamptothecin exhibits potent antitumor properties, primarily through its mechanism of inhibiting the enzyme topoisomerase I, which is essential for DNA replication and transcription. This inhibition leads to DNA damage and ultimately triggers apoptosis in cancer cells. The compound is typically a pale yellow solid and is soluble in organic solvents, making it suitable for various pharmaceutical formulations. Its stability can be affected by pH and temperature, which is important for its storage and handling. O-acetylcamptothecin has been studied for its potential in cancer therapy, and ongoing research aims to optimize its efficacy and reduce side effects associated with its use. As with many chemotherapeutic agents, careful consideration of dosage and administration is critical to maximize therapeutic benefits while minimizing toxicity.
Formula:C22H18N2O5
InChI:InChI=1/C22H18N2O5/c1-3-22(29-12(2)25)16-9-18-19-14(8-13-6-4-5-7-17(13)23-19)10-24(18)20(26)15(16)11-28-21(22)27/h4-9H,3,10-11H2,1-2H3
Synonyms:- O-acetylcamptothecin
- 20-O-Acetylcamptothecin
- 1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-(acetyloxy)-4-ethyl-, (4S)-
- 4-Ethyl-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-4-yl acetate
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 2 products.
