CAS 769-42-6

Dimethylbarbituric acid

Description:

Dimethylbarbituric acid, with the CAS number 769-42-6, is a chemical compound that belongs to the barbiturate class of drugs, which are derivatives of barbituric acid. It is characterized by its structure, which includes two methyl groups attached to the nitrogen atoms of the barbituric acid framework. This compound is typically a white crystalline solid that is soluble in water and exhibits weakly acidic properties due to the presence of carboxylic acid functional groups. Dimethylbarbituric acid is known for its sedative and hypnotic effects, although it is less commonly used in clinical settings compared to other barbiturates. Its pharmacological activity is attributed to its ability to modulate the activity of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to central nervous system depression. Additionally, it has applications in biochemical research and as an intermediate in organic synthesis. Safety and handling precautions are essential due to its potential for toxicity and dependence.

Formula: C₆H₈N₂O₃

InChI: InChI=1/C6H8N2O3/c1-7-4(9)3-5(10)8(2)6(7)11/h3H2,1-2H3

InChI key: InChIKey=VVSASNKOFCZVES-UHFFFAOYSA-N

SMILES: CN1C(=O)N(C)C(=O)CC1=O

Synonyms:

• 1,3-Dimethyl-1,3-diazacyclohexane-2,4,6-trione
• 1,3-Dimethyl-1,3-diazinane-2,4,6-trione
• 1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
• 1,3-Dimethyl-pyrimidine-2,4,6-trione
• 1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
• 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dimethyl-
• 6-Hydroxy-1,3-dimethyluracil
• Barbituric acid, 1,3-dimethyl-
• Dimethylbarbituric acid
• N,N'-Dimethylbarbituric acid
• N,N′-Dimethyl-2,4,6-pyrimidinetrione
• Nsc 61918
• 1,3-Dimethylbarbituric acid
• 1,3-Dimethylpyrimidine-2,4,6(1H,2H,5H)-trione
• 1,3-Dimethylhexahydropyrimidine-2,4,6-trione
• AKOS B029702
• 1,3-Dimethylbarbituric acid, 99% (dry wt.) water < 6%
• Hexahydro-1,3-dimethylpyrimidine-2,4,6-trione
• 1,3-dimethyl-4,6(1h,3h,5h)-pyrimidinetrione
• 1,3-Dimethyl-2,4,6-Trihydroxy-Pyrimidine
• 6(1h,3h,5h)-pyrimidinetrione,1,3-dimethyl-4

1,3-Dimethylbarbituric acid, 99% (dry wt.), water &lt;6%

CAS: 769-42-6

1,3-Dimethylbarbituric acid is used as a catalyst in the Knoevenagel condensation of a series of aromatic aldehydes. It is also used in the synthesis of 5-aryl-6-(alkyl- or aryl-amino)-1,3-dimethylfuro [2,3-d]pyrimidine derivatives and enantioselective synthesis of isochromene pyrimidinedione deriva

Formula: C₆H₈N₂O₃

Purity: 99%

Color and Shape: White to cream or pale yellow, Crystals or powder or crystalline powder

Molecular weight: 156.14

Ref: 02-A13692

1,3-Dimethylbarbituric acid

CAS: 769-42-6

Formula: C₆H₈N₂O₃

Purity: 97%

Color and Shape: Solid

Molecular weight: 156.1393

Ref: IN-DA003DKC

1,3-Dimethylbarbituric acid

CAS: 769-42-6

Formula: C₆H₈N₂O₃

Purity: ≥ 99.0%

Color and Shape: White to off-white crystalline powder

Molecular weight: 156.14

Ref: 7W-GX0205

1,3-Dimethylbarbituric acid

CAS: 769-42-6

1,3-Dimethylbarbituric acid

Purity: 99%

Molecular weight: 156.14g/mol

Ref: 54-OR1002579

Urapidil Impurity 4 (1,3-Dimethylbarbituric Acid)

CAS: 769-42-6

Formula: C₆H₈N₂O₃

Color and Shape: White To Off-White Solid

Molecular weight: 156.14

Ref: 4Z-U-0710

1,3-Dimethylbarbituric Acid

CAS: 769-42-6

Formula: C₆H₈N₂O₃

Purity: >98.0%(GC)(T)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 156.14

Ref: 3B-D1618

1,3-Dimethylbarbituric Acid

CAS: 769-42-6

Color and Shape: Neat

Ref: 86-MM3980.05

1,3-Dimethyl Barbituric Acid

Controlled Product

CAS: 769-42-6

Applications 1,3-Dimethyl Barbituric Acid (Urapidil Impurity 4) is a derivative of Barbituric acid (B118650). All of the barbituric acid derivatives which have been reported to have pronounced hypnotic activity are disubstituted in the 5-position.
References Gupta, K., et al.: Eur. J. Med. Chem., 17, 448 (1982), Weber, L., et al.: Curr. Med. Chem., 9, 2085 (2002), Skiles, J., et al.: Curr. Med. Chem., 11, 2911 (2004),

Formula: C₆H₈N₂O₃

Color and Shape: Neat

Molecular weight: 156.14

Ref: TR-D463650

1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione

Controlled Product

CAS: 769-42-6

1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione is a heterocyclic organic compound, which is synthesized via established chemical procedures involving catalytic methods or direct condensation reactions. This compound is well-known for its role in the biochemical field as a urease inhibitor. Urease, an enzyme that catalyzes the hydrolysis of urea, is targeted by this compound to potentially mitigate issues related to excessive ammonia production in agricultural and medical settings.In addition to its enzymatic inhibition properties, 1,3-Dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione serves as a pivotal intermediate in barbiturate synthesis. Barbiturates are psychoactive compounds used historically in medicine for their sedative and anesthetic properties. The compound's structure allows it to participate in the Knoevenagel condensation, facilitating the formation of complex molecules essential in pharmaceutical development. These multifunctional applications make it a valuable tool in various scientific research contexts, exploring both inhibitory mechanisms and synthetic pathways for drug discovery and development.

Formula: C₆H₈N₂O₃

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 156.14 g/mol

Ref: 3D-FD128015

1,3-Dimethylbarbituric acid

CAS: 769-42-6

Formula: C₆H₈N₂O₃

Purity: 98.0%

Molecular weight: 156.141

Ref: 10-F078986

Urapidil Impurity 4

CAS: 769-42-6

Formula: C₆H₈N₂O₃

Molecular weight: 156.14

Ref: ST-EA-CP-U2004