CAS 769141-88-0

Guanosine,8-bromo-2'-deoxy-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-

Description:

Guanosine, 8-bromo-2'-deoxy-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]- is a modified nucleoside that features a guanine base attached to a deoxyribose sugar. The presence of the 8-bromo substitution on the guanine ring enhances its reactivity and can influence its biological activity, potentially affecting interactions with nucleic acids. The compound is further modified with a siloxane moiety, specifically a tetrakis(1-methylethyl)-1,3-disiloxanediyl group, which introduces unique steric and electronic properties. This siloxane modification can enhance solubility and stability in various environments, making it useful in biochemical applications. The compound's structure suggests potential uses in nucleic acid research, drug development, or as a biochemical probe. Its CAS number, 769141-88-0, allows for precise identification in chemical databases. Overall, this compound exemplifies the complexity and versatility of modified nucleosides in chemical and biological research.

Formula: C₂₂H₃₈BrN₅O₅Si₂

Synonyms:

• 8-Bromo-N9-[3’,5’-O-(1,1,3,3-tetrakis(isopropyl)-1,3-disiloxanediyl)--D-2’-deoxyribofuranosyl]guanine

8-Bromo-9-[3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-deoxy-b-D-ribofuranosyl]guanine

CAS: 769141-88-0

8-Bromo-9-[3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-deoxy-b-D-ribofuranosyl]guanine is a nucleoside analog that inhibits DNA synthesis in the cancer cells. This agent is an activator of nucleases and can inhibit RNA synthesis by inhibiting the enzyme ribonucleotide reductase. 8-Bromo-9-[3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-2'-deoxy-b-Dribofuranosyl]guanine also has antiviral activity against herpes simplex virus type 1 and 2. The drug is a novel compound with anticancer activity that targets DNA synthesis by binding to the enzyme topoisomerase II. This

Formula: C₂₂H₃₈BrN₅O₅Si₂

Purity: Min. 95%

Molecular weight: 588.64 g/mol

Ref: 3D-NB04668