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CAS 76924-93-1

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Iodine-123 metaiodobenzylguanidine

Description:
Iodine-123 metaiodobenzylguanidine (MIBG) is a radiopharmaceutical compound primarily used in nuclear medicine for diagnostic imaging and therapeutic purposes, particularly in the evaluation of neuroendocrine tumors, such as pheochromocytomas and neuroblastomas. It is a derivative of guanidine, where a benzyl group is substituted with an iodine-123 isotope, which is a gamma-emitting radioisotope. This characteristic allows for the visualization of tissues and organs through single-photon emission computed tomography (SPECT) imaging. MIBG is selectively taken up by adrenergic tissues, making it particularly useful for targeting tumors that express norepinephrine transporters. The compound is typically administered intravenously and has a relatively short half-life, which necessitates careful handling and administration in a clinical setting. Its use is governed by strict regulatory guidelines due to its radioactive nature, and it is essential for healthcare providers to monitor patients for potential side effects, including allergic reactions or changes in blood pressure. Overall, Iodine-123 MIBG plays a crucial role in the diagnosis and management of specific types of cancer.
Formula:C8H10IN3
InChI:InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)/i9-4
InChI key:InChIKey=PDWUPXJEEYOOTR-IUAIQHPESA-N
SMILES:C(NC(=N)N)C1=CC([123I])=CC=C1
Synonyms:
  • [123I]-m-Iodobenzylguanidine
  • m-Iodobenzylguanidine-123I
  • Guanidine, [[3-(iodo-123I)phenyl]methyl]-
  • N-[[3-(Iodo-123I)phenyl]methyl]guanidine
  • Guanidine, N-[[3-(iodo-123I)phenyl]methyl]-
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