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CAS 7698-93-3

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Estradiol hemisuccinate

Description:
Estradiol hemisuccinate is a synthetic derivative of estradiol, a naturally occurring estrogen hormone. It is characterized by the addition of a hemisuccinate group, which enhances its solubility and bioavailability. This compound typically appears as a white to off-white powder and is soluble in organic solvents like ethanol and dimethyl sulfoxide, but less soluble in water. Estradiol hemisuccinate is primarily used in hormone replacement therapy and in various pharmaceutical formulations aimed at treating conditions related to estrogen deficiency. Its mechanism of action involves binding to estrogen receptors, thereby influencing gene expression and cellular activity related to reproductive and other physiological processes. The compound is also studied for its potential effects on bone density, cardiovascular health, and menopausal symptoms. Safety and efficacy profiles are essential considerations in its use, as with any hormone therapy, to mitigate risks associated with estrogen administration.
Formula:C22H28O5
InChI:InChI=1/C22H28O5/c1-22-11-10-16-15-5-3-14(23)12-13(15)2-4-17(16)18(22)6-7-19(22)27-21(26)9-8-20(24)25/h3,5,12,16-19,23H,2,4,6-11H2,1H3,(H,24,25)/t16-,17-,18+,19+,22+/m1/s1
InChI key:InChIKey=YJPIDPAGJSWWBE-FNIAAEIWSA-N
SMILES:C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC[C@@H]2OC(CCC(O)=O)=O)[H]
Synonyms:
  • 17beta-Estradiol hemisuccinate
  • 17β-Estradiol succinate
  • 4-{[(17Beta)-3-Hydroxyestra-1,3,5(10)-Trien-17-Yl]Oxy}-4-Oxobutanoic Acid
  • Estra-1,3,5(10)-triene-3,17-diol (17beta)-, 17-(hydrogen butanedioate)
  • Estra-1,3,5(10)-triene-3,17-diol (17β)-, 17-(hydrogen butanedioate)
  • Estra-1,3,5(10)-triene-3,17β-diol 17-(hydrogen succinate)
  • Estradiol 17β-hemisuccinate
  • Estradiol hemisuccinate
  • Estradiol, 17-(hydrogen succinate)
  • Estradiol-17-hemisuccinate
  • See more synonyms
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