CAS 77-36-1
:Chlorthalidone
Description:
Chlorthalidone is a thiazide-like diuretic commonly used in the treatment of hypertension and edema associated with heart failure, liver cirrhosis, and renal disorders. It is characterized by its ability to inhibit sodium reabsorption in the distal convoluted tubule of the nephron, leading to increased excretion of sodium and water, which helps lower blood pressure and reduce fluid retention. Chlorthalidone has a long half-life, allowing for once-daily dosing, and it is often preferred for its sustained antihypertensive effects. The compound is typically administered in oral form and is known for its effectiveness in managing high blood pressure, often in combination with other antihypertensive agents. In addition to its primary uses, chlorthalidone may also have beneficial effects on calcium metabolism and is sometimes used to prevent kidney stones. Its chemical structure includes a sulfonamide group, contributing to its diuretic properties. As with any medication, potential side effects include electrolyte imbalances, particularly hypokalemia, and it is important for patients to be monitored regularly during treatment.
Formula:C14H11ClN2O4S
InChI:InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChI key:InChIKey=JIVPVXMEBJLZRO-UHFFFAOYSA-N
SMILES:OC1(C=2C(C(=O)N1)=CC=CC2)C3=CC(S(N)(=O)=O)=C(Cl)C=C3
Synonyms:- (.+-.)-Hygroton
- 1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxy-isoindolinum
- 1-Oxo-3-(3-sulfamyl-4-chlorophenyl)-3-hydroxyisoindoline
- 1-Oxo-3-(4'-chloro-3'-sulphamoylphenyl)-3-hydroxyisoindoline
- 1-keto-3-(3'-Sulfamyl-4'-chlorophenyl)-3-hydroxyisoindoline
- 2-Chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)benzenesulfonamide
- 2-Chloro-5-(1-hydroxy-3-oxo-2H-isoindol-1-yl)benzenesulfonamide
- 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)benzenesulfonamide
- 2-Chloro-5-(3-hydroxy-1-oxoisoindol-3-yl)benzenesulfonamide
- 2-chloro-5-(1-hydroxy-3-oxo-2,3-dihydro-1H-isoindol-1-yl)benzenesulfonamide
- 3-(4'-Chloro-3'-sulfamoylphenyl)-3-hydroxyphthalimidine
- 3-(4-Chloro-3-Sulphamoylphenyl)-3-Hydroxyisoindolin-1-One
- 3-Hydroxy-3-[4-chloro-3-sulfamylphenyl]phthalimidine
- Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-
- Benzenesulfonamide, 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-
- Chlorothalidone
- Chlortalidon
- Chlortalidone
- Chlorthalidon
- Clortalidona
- Demi-Regroton
- G 33182
- Higroton
- Higrotona
- Igroton
- Isoren
- Natriuran
- Nsc 69200
- Oradil
- Oxodolin
- Phthalamudine
- Racemic chlorthalidone
- Renon
- Saluretin
- Thalitone
- Zambesil
- Zinc 00020253
- 2-chloro-5-(1-hydroxy-3-keto-isoindolin-1-yl)benzenesulfonamide
- chlorphthalidone
- 3-[4-Chloro-3-(sulfamoyl)phenyl]-3-hydroxy-3H-isoindol-1(2H)-one
- CHLORTHALIDONE
- hydroton
- g33182
- Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)- (6CI, 8CI)
- phthalamodine
- 2-Chloro-5-(1-hydroxy-3-oxoisoindolin-1-yl)benzenesulfonaMide
- chlorphthalidolone
- Clortalidone
- 1-(4-Chloro-3-sulphamoylphenyl)-1-hydroxyisoindolin-3-one
- NSC 6920
- CHLORTHALIDONE,USP
- 2-chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1h-isoindol-1-yl)-benzenesulfonamid
- Chlorthalidone (200 mg)
- See more synonyms
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Found 15 products.
Chlortalidone
CAS:Formula:C14H11ClN2O4SPurity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:338.76Chlortalidone
CAS:ChlortalidoneFormula:C14H11ClN2O4SPurity:99.1%Color and Shape:White SolidMolecular weight:338.01281Chlorthalidone
CAS:Sulfonamides used as drugsFormula:C14H11ClN2O4SColor and Shape:White Yellow Crystalline PowderMolecular weight:338.01281Chlortalidone (Chlorthalidone)
CAS:Formula:C14H11ClN2O4SColor and Shape:White To Off-White SolidMolecular weight:338.76Chlorthalidone
CAS:Formula:C14H11ClN2O4SPurity:≥ 98.0%Color and Shape:White to beige powderMolecular weight:338.772-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide
CAS:Controlled Product2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide is a drug that belongs to the class of sulfonamides which is used in pharmaceutical formulations. It has been shown to have potent antihypertensive effects, and it also lowers blood pressure by inhibiting an enzyme called carbonic anhydrase. 2CCHIB binds to the chloride channel in kidney tubule cells and prevents the reabsorption of chloride ions in these cells. This leads to more water being excreted from the body, which reduces blood volume and pressure. The low density lipoprotein (LDL) cholesterol levels are also reduced when this drug is taken orally. 2CCHIB increases high sensitivity C reactive protein (hsCRP), a marker for inflammation, but it can also have antioxidant effects.Formula:C14H11ClN2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:338.77 g/molChlorthalidone - Bio-X ™
CAS:Controlled ProductChlorthalidone is a thiazide-diuretic that is used to treat hypertension and edema caused by conditions such as renal failure, hepatic cirrhosis and estrogen therapy. It lowers blood pressure by inhibiting an enzyme called carbonic anhydrase. Chlorthalidone binds to the chloride channel in kidney tubule cells and prevents the reabsorption of chloride ions in these cells. This leads to more water being excreted from the body, which reduces blood volume and pressure.
Formula:C14H11ClN2O4SPurity:Min. 95%Color and Shape:PowderMolecular weight:338.77 g/molChlorthalidone Impurity G-d4
CAS:Controlled ProductApplications Isotope labelled Chlorthalidone (C427500) impurity. Antihypertensive agent.
References Beisenherz, et al.: Arch. Int. Pharmacodyn. Ther., 161, 76 (1966), Zsoter, et al.: J. Pharmacol. Exp. Ther., 180, 723 (1972), Singer, J.M., et al.: Anal. Profiles Drug Subs., 14, 1 (1985),Formula:C14D4H5Cl2NO2Color and Shape:NeatMolecular weight:298.157
