CAS 77-46-3

Acedapsone

Description:

Acedapsone, with the CAS number 77-46-3, is a sulfone antibiotic that is primarily used in the treatment of leprosy and certain skin infections. It is a derivative of dapsone, exhibiting similar antimicrobial properties. Acedapsone is characterized by its ability to inhibit bacterial growth by interfering with folate synthesis, which is crucial for bacterial cell metabolism. The compound is typically presented as a white to off-white crystalline powder, and it is soluble in organic solvents but has limited solubility in water. Its chemical structure includes a sulfone group, which contributes to its biological activity. Acedapsone is generally administered orally and is known for its relatively long half-life, allowing for less frequent dosing compared to some other antibiotics. As with many sulfone compounds, it may cause side effects, including hypersensitivity reactions, and requires monitoring for potential hematological effects. Overall, acedapsone plays a significant role in the management of specific infectious diseases, particularly in regions where leprosy remains a public health concern.

Formula: C₁₆H₁₆N₂O₄S

InChI: InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20)

InChI key: InChIKey=AMTPYFGPPVFBBI-UHFFFAOYSA-N

SMILES: S(=O)(=O)(C1=CC=C(NC(C)=O)C=C1)C2=CC=C(NC(C)=O)C=C2

Synonyms:

• 1399 F
• 1399F
• 4',4'''-Sulfonylbis(acetanilide)
• 4',4'''-Sulfonylbis(acetanilidec)
• 4,4'-Bis(acetylamino)diphenyl sulfone
• 4,4'-Diacetamidodiphenyl sulfone
• 4,4'-Diacetylaminodiphenyl sulfone
• 4,4'-Diacetyldiaminodiphenyl sulfone
• 4,4′-Sulfonylbisacetanilide
• Acedafsonum
• Acedafsonum [Latin]
• Acedapsona
• Acedapsona [INN-Spanish]
• Acedapsona [Spanish]
• Acedapsone [USAN:INN:BAN]
• Acedapsonum
• Acedapsonum [INN-Latin]
• Acetamide. N,N'-(sulfonyldi-4,1-phenylene)bis-
• Acetamin
• Acetamin (antibacterial)
• Acetanilide, 4',4'''-sulfonylbis-
• Acetanilide, 4',4'''-sulfonyldi-
• Acetanilide, 4′,4′′′-sulfonylbis-
• Ai3-32581
• Atilon
• Ba 2650
• Bis(4-acetamidophenyl) sulfone
• Bis(p-acetamidophenyl) sulfone
• Brn 2164071
• Camilan
• Ccris 5694
• Ci 556
• Cn 1883
• Dadds
• Di-(p-acetylaminophenyl)sulfone
• Diacetyldapsone
• Hansolar
• N,N'-(Sulfonyldi-4,1-phenylene)bisacetamide
• N,N'-(sulfonyldibenzene-4,1-diyl)diacetamide
• N,N'-Diacetyl-4,4'-diaminodiphenyl sulfone
• N,N'-Diacetyl-4,4'-diaminodiphenylsulfone
• N,N'-Diacetyl-4,4'-diaminophenyl sulfone
• N,N'-Diacetyldapsone
• N,N′-(Sulfonyldi-4,1-phenylene)bis[acetamide]
• Nsc 218125
• Nsc 655049
• Pam-Mr-1165
• Rodilone
• Sulfadiamine
• Sulfodiamin
• Sulfodiamine
• Sulfone, bis(p-acetamidophenyl)
• Unii-0Gz72U84Tn
• p,p'-Sulfonylbisacetanilide

Acedapsone

CAS: 77-46-3

Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.

Formula: C₁₆H₁₆N₂O₄S

Purity: 98%

Color and Shape: Solid

Molecular weight: 332.37

Ref: TM-T26549

Acedapsone

CAS: 77-46-3

Acedapsone is in a class of drugs called sulfonamides. It is used to treat leprosy, which is caused by Mycobacterium leprae. Acedapsone inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human erythrocytes. This active form is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. Acedapsone also specifically binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.

Formula: C₁₆H₁₆N₂O₄S

Purity: Min. 95%

Molecular weight: 332.4 g/mol

Ref: 3D-AAA07746