CAS 770691-21-9

Gadobutrol

Description:

Gadobutrol is a gadolinium-based contrast agent primarily used in magnetic resonance imaging (MRI) to enhance the visibility of internal structures. It is characterized by its high relaxivity, which allows for improved imaging quality. Gadobutrol is a non-ionic, paramagnetic compound that contains gadolinium, a rare earth metal known for its strong magnetic properties. The substance is water-soluble and is typically administered intravenously. One of its notable features is its low osmolality, which contributes to a reduced risk of adverse reactions compared to older contrast agents. Gadobutrol is also designed to be stable and non-toxic, minimizing the risk of nephrotoxicity, particularly in patients with compromised kidney function. Its chemical structure includes a butrol moiety, which enhances its pharmacokinetic properties. Overall, Gadobutrol is recognized for its efficacy in providing clear and detailed images during MRI procedures, making it a valuable tool in medical diagnostics.

Formula: C₁₈H₃₁GdN₄O₉

InChI: InChI=1/C18H34N4O9.Gd/c23-12-14(15(25)13-24)22-7-5-20(10-17(28)29)3-1-19(9-16(26)27)2-4-21(6-8-22)11-18(30)31;/h14-15,23-25H,1-13H2,(H,26,27)(H,28,29)(H,30,31);/q;+3/p-3/t14-,15-;/s2

InChI key: InChIKey=ZPDFIIGFYAHNSK-ZCTZICQLNA-K

SMILES: C(O)[C@H]1[N]23[Gd+3]45678([N](CC2)(CC[N]4(CC[N]5(CC3)CC(=O)[O-]6)CC(=O)[O-]7)CC(=O)[O-]8)[OH][C@@H]1CO

Synonyms:

• (SA-8-1425362′5′)-[rel-10-[(2R,3S)-2-(Hydroxy-κO)-3-hydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-κN1,κN4,κN7,κN10,κO1,κO4,κO7]gadolinium
• Gadobutrol
• Gadovist
• Gadolinium, [10-[2-(hydroxy-κO)-3-hydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-κN1,κN4,κN7,κN10,κO1,κO4,κO7]-, [SA-8-1425362′5′-(R*,S*)]-
• Gadolinium, [rel-10-[(2R,3S)-2-(hydroxy-κO)-3-hydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-κN1,κN4,κN7,κN10,κO1,κO4,κO7]-, (SA-8-1425362′5′)-
• ZK 135079
• Protovist
• Gadograf

Gadobutrol

CAS: 770691-21-9

Gadobutrol

Molecular weight: 604.71g/mol

Ref: 54-BUP05669

Gadobutrol

CAS: 770691-21-9

Gadobutrol is a nonionic, paramagnetic contrast agent developed for tissue contrast enhancement in magnetic resonance imaging (MRI)

Formula: C₁₈H₃₁GdN₄O₉

Purity: 98%

Color and Shape: Solid

Molecular weight: 604.71

Ref: TM-T8406

Gadobutrol

CAS: 770691-21-9

Applications Gadobutrol is a gadolinium-based MRI contrast agent (GBCA).
References Laurent, S., et al.: Contrast Media Mol. Imaging, 1, 128 (2006); Frenzel, T., et al.: Invest. Radiol., 43, 817 (2008)

Formula: C₁₈H₃₁GdN₄O₉

Color and Shape: Neat

Molecular weight: 604.71

Ref: TR-G125705

Gadobutrol

CAS: 770691-21-9

Gadobutrol is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) to improve the visibility of blood vessels. Gadobutrol has potential side effects, such as liver lesions and heart problems. These side effects are rare and have been seen only in animals that were given gadobutrol intravenously. Gadolinium is not known to cause any other adverse effects, but it can be toxic if ingested or inhaled. Gadobutrol is injected into the bloodstream and accumulates in the body's tissues, including the brain, kidneys, bones, and liver. MRI scans are considered safe for most patients with kidney disease, but gadobutrol should not be used by those who have severe kidney disease or by pregnant women because of its potential to cross the placenta and enter fetal tissue.

Formula: C₁₈H₃₁GdN₄O₉

Purity: Min. 95%

Molecular weight: 604.71 g/mol

Ref: 3D-VFB69121