CAS 77086-21-6

Dizocilpine

Description:

Dizocilpine, also known as MK-801, is a potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, which plays a crucial role in synaptic plasticity and memory function. It is primarily used in research settings to study the effects of NMDA receptor inhibition on various neurological and psychiatric conditions. The compound exhibits a high affinity for the NMDA receptor, leading to significant neuroprotective effects in certain experimental models. Dizocilpine is characterized by its ability to induce dissociative anesthesia and has been investigated for its potential therapeutic applications in conditions such as schizophrenia and neurodegenerative diseases. However, its use is limited due to side effects, including cognitive impairment and psychotomimetic effects. As a chemical entity, dizocilpine is classified as a synthetic compound with a specific molecular structure that contributes to its pharmacological properties. Safety and handling precautions are essential when working with this substance, as it can have profound effects on the central nervous system.

Formula: C₁₆H₁₅N

InChI: InChI=1S/C16H15N/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16/h2-9,15,17H,10H2,1H3/t15-,16+/m1/s1

InChI key: InChIKey=LBOJYSIDWZQNJS-CVEARBPZSA-N

SMILES: C[C@]12C=3C([C@](N1)(CC=4C2=CC=CC4)[H])=CC=CC3

Synonyms:

• (5S,10R)-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-imine
• (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene
• 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-
• 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)-
• Dizocilpina
• Dizocilpina [INN-Spanish]
• Dizocilpine [INN]
• Dizocilpinum
• Dizocilpinum [INN-Latin]
• Hsdb 7641
• Mk 801
• Unii-7Py8Kh681I

Dizocilpine

CAS: 77086-21-6

Formula: C₁₆H₁₅N

Purity: 98%

Color and Shape: Solid

Molecular weight: 221.2970

Ref: IN-DA00G6XB

Dizocilpine

CAS: 77086-21-6

Dizocilpine

Purity: ≥98%

Molecular weight: 221.3g/mol

Ref: 54-BUP10227

Dizocilpine

CAS: 77086-21-6

Purity: 98%

Molecular weight: 221.302993774414

Ref: 10-F601071

Dizocilpine

CAS: 77086-21-6

MK-801 (Dizocilpine (MK-801)) is a potent N-methyl-D-aspartate (NMDA) receptor antagonist with Ki of 30.5 nM.

Formula: C₁₆H₁₅N

Purity: 99.85% - 99.97%

Color and Shape: Solid

Molecular weight: 221.3

Ref: TM-T6259

Dizocilpine

CAS: 77086-21-6

Dizocilpine is a drug that belongs to the group of non-steroidal anti-inflammatory drugs, and it is an antagonist of the NMDA receptor. It has been shown to decrease 5HT concentrations in brain tissue and reduce the number of bowel disease symptoms. Dizocilpine inhibits signal peptide processing of proteins and prevents their release from cells by inhibiting protein synthesis. It also has been found to antagonize NMDA receptors, which are enzymes involved in signal transmission between neurons. The NMDA receptor has been shown to be a target for pharmacological agents that have antidepressant effects. Dizocilpine is believed to have therapeutic properties for depression and bowel disease.

Formula: C₁₆H₁₅N

Purity: Min. 95%

Molecular weight: 221.3 g/mol

Ref: 3D-CDA08621