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CAS 77086-22-7

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MK 801

Description:
MK-801, also known as dizocilpine, is a potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, which plays a crucial role in synaptic plasticity and memory function. It is primarily used in research settings to study the effects of NMDA receptor inhibition on various neurological and psychiatric conditions. MK-801 is characterized by its ability to block the ion channel of the NMDA receptor, thereby preventing the influx of calcium ions, which can lead to excitotoxicity. This compound is known for its neuroprotective properties in certain experimental models, but it can also induce psychotomimetic effects, making it a valuable tool for studying schizophrenia and other disorders. MK-801 is typically administered in animal studies and is not approved for human use due to its potential for abuse and adverse effects. Its chemical structure includes a phenyl ring and a piperidine moiety, contributing to its pharmacological profile. As with all research chemicals, handling MK-801 requires caution due to its potent effects and potential toxicity.
Formula:C16H15N·C4H4O4
InChI:InChI=1/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1
SMILES:C[C@]12C=3C([C@](N1)(CC=4C2=CC=CC4)[H])=CC=CC3.C(=C\C(O)=O)\C(O)=O
Synonyms:
  • (+)-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammoniummaleat
  • (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate
  • (+)-Mk 801
  • (+/-)-Mk-801 Hydrogen Maleate
  • (5R,10S)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
  • (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
  • 5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
  • 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (2Z)-2-butenedioate (1:1)
  • 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1)
  • 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)-, (2Z)-2-butenedioate (1:1)
  • See more synonyms
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