CAS 77086-22-7

MK 801

Description:

MK-801, also known as dizocilpine, is a potent non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, which plays a crucial role in synaptic plasticity and memory function. It is primarily used in research settings to study the effects of NMDA receptor inhibition on various neurological and psychiatric conditions. MK-801 is characterized by its ability to block the ion channel of the NMDA receptor, thereby preventing the influx of calcium ions, which can lead to excitotoxicity. This compound is known for its neuroprotective properties in certain experimental models, but it can also induce psychotomimetic effects, making it a valuable tool for studying schizophrenia and other disorders. MK-801 is typically administered in animal studies and is not approved for human use due to its potential for abuse and adverse effects. Its chemical structure includes a phenyl ring and a piperidine moiety, contributing to its pharmacological profile. As with all research chemicals, handling MK-801 requires caution due to its potent effects and potential toxicity.

Formula: C₁₆H₁₅N·C₄H₄O₄

InChI: InChI=1/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1

SMILES: C[C@]12C=3C([C@](N1)(CC=4C2=CC=CC4)[H])=CC=CC3.C(=C\C(O)=O)\C(O)=O

Synonyms:

• (+)-10,11-Dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammoniummaleat
• (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cyclohepten-5,10-diyldiammonium maleate
• (+)-Mk 801
• (+/-)-Mk-801 Hydrogen Maleate
• (5R,10S)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
• (5S,10R)-5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
• 5-methyl-10,11-dihydro-5H-5,10-epiminodibenzo[a,d][7]annulene (2Z)-but-2-enedioate
• 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (2Z)-2-butenedioate (1:1)
• 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S)-, (Z)-2-butenedioate (1:1)
• 5H-Dibenzo[a,d]cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (5S,10R)-, (2Z)-2-butenedioate (1:1)
• Dizocilpine hydrogen maleate
• Dizocilpine maleate
• maleate de (+)-10,11-dihydro-5-methyl-5H-dibenzo[a,d]cycloheptene-5,10-diyldiammonium

Dizocilpine maleate, 99+%

CAS: 77086-22-7

NMDA receptor antagonist that prevents calcium flux

Formula: C₂₀H₁₉NO₄

Purity: 99+%

Color and Shape: Powder or crystals or crystalline powder

Molecular weight: 337.38

Ref: 02-J63917

(+)-MK 801 maleate

CAS: 77086-22-7

M03845 - (+)-MK 801 maleate

Formula: C₂₀H₁₉NO₄

Purity: >98%

Color and Shape: Solid, No data available.

Molecular weight: 337.375

Ref: 10-M03845

(5S,​10R)​-​10,​11-​Dihydro-​5-​methyl-​5H-​dibenzo[a,​d]​cyclohepten-​5,​10-​imine Maleate

CAS: 77086-22-7

Formula: C₂₀H₁₉NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 337.3692

Ref: IN-DA005EFH

(5S,10R)-5-Methyl-10,11-Dihydro-5H-5,10-Epiminodibenzo[A,D][7]Annulene Maleate

CAS: 77086-22-7

(5S,10R)-5-Methyl-10,11-Dihydro-5H-5,10-Epiminodibenzo[A,D][7]Annulene Maleate

Purity: 98%

Molecular weight: 337.37g/mol

Ref: 54-OR1023142

Dizocilpine Maleate

CAS: 77086-22-7

Dizocilpine Maleate

Purity: ≥98%

Molecular weight: 337.38g/mol

Ref: 54-BUP13483

(+)-MK-801 hydrogen maleate

CAS: 77086-22-7

Formula: C₁₆H₁₅N·C₄H₄O₄

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 337.37

Ref: 7W-GL1394

(+)-MK 801 Maleate

CAS: 77086-22-7

Formula: C₁₆H₁₅N·C₄H₄O₄

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 337.38

Ref: 3B-M3393

Dizocilpine Maleate

CAS: 77086-22-7

Dizocilpine Maleate (MK 801) is a potent noncompetitive antagonist of the NMDA receptor with Kd of 37.2 nM in rat brain membranes.

Formula: C₂₀H₁₉NO₄

Purity: 99% - 99.96%

Color and Shape: White Solid

Molecular weight: 337.38

Ref: TM-T3320

(+)-MK 801 Hydrogen Maleate

Controlled Product

CAS: 77086-22-7

Applications (+)-MK 801 Hydrogen Maleate acts as an NMDA receptor antagonist. It is selective and potent, but noncompetitive, used in various ischemia treatments.
References Ma, J. et al.: Hippocamp., 22, 2208 (2012); Cao, Z. et al.: Toxicol. Sci., 130, 362 (2012);

Formula: C₁₆H₁₅N·C₄H₄O₄

Color and Shape: Neat

Molecular weight: 337.37

Ref: TR-M424950

(+)-MK 801 maleate

CAS: 77086-22-7

NMDA glutamate receptor antagonist

Formula: C₁₆H₁₅N·C₄H₄O₄

Purity: Min. 98 Area-%

Color and Shape: Powder

Molecular weight: 337.37 g/mol

Ref: 3D-BM162595