Phosphodiesterase 3',5'-cyclic nucleotide-activating enzyme, commonly referred to as phosphodiesterase (PDE), is an enzyme that plays a crucial role in cellular signaling by hydrolyzing cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP). This action regulates various physiological processes, including vasodilation, neurotransmission, and cell growth. The enzyme is characterized by its specificity for cyclic nucleotides, with different isoforms exhibiting varying affinities and regulatory mechanisms. PDEs are integral in modulating the levels of these second messengers, thus influencing numerous signaling pathways. The inhibition of phosphodiesterase activity has therapeutic implications, particularly in cardiovascular diseases, erectile dysfunction, and certain psychiatric disorders. The CAS number 77107-46-1 specifically identifies a particular form or isoform of this enzyme, which may have distinct biochemical properties and regulatory mechanisms compared to other phosphodiesterases. Understanding the characteristics and functions of this enzyme is essential for developing targeted therapies that manipulate cyclic nucleotide signaling in various clinical contexts.

phosphodiesterase 3':5'-cyclic*nucleotide-activat

77107-46-1: Phosphodiesterase 3',5'-cyclic nucleotide-activating enzyme, commonly referred to as phosphodiesterase (PDE), is an enzyme that plays a crucial role in cellular signaling by hydrolyzing cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP). This action regulates various physiological processes, including vasodilation, neurotransmission, and cell growth. The enzyme is characterized by its specificity for cyclic nucleotides, with different isoforms exhibiting varying affinities and regulatory mechanisms. PDEs are integral in modulating the levels of these second messengers, thus influencing numerous signaling pathways. The inhibition of phosphodiesterase activity has therapeutic implications, particularly in cardiovascular diseases, erectile dysfunction, and certain psychiatric disorders. The CAS number 77107-46-1 specifically identifies a particular form or isoform of this enzyme, which may have distinct biochemical properties and regulatory mechanisms compared to other phosphodiesterases. Understanding the characteristics and functions of this enzyme is essential for developing targeted therapies that manipulate cyclic nucleotide signaling in various clinical contexts.

Calmodulin is a protein that binds to and regulates the activity of many enzymes, including target enzymes. It has been shown to bind to DNA and regulate transcription. Calmodulin can also bind to the cytosolic calcium ion (Ca2+) and regulate its activity by controlling intracellular levels of this ion. The binding of calmodulin to Ca2+ in the cell allows for changes in membrane potential, which leads to neuronal death. Calmodulin is also involved in the regulation of enzyme activities, such as those involved in cellular respiration and detoxification reactions. This protein has been implicated in structural heart disease because it is an intracellular target for pharmacological agents that are used for treatment of cardiovascular diseases.

CAS 77107-46-1

phosphodiesterase 3':5'-cyclic*nucleotide-activat

Calmodulin

Ref: 3D-FC171039