CAS 77128-69-9

5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-L-methioninamide

Description:

5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-L-methioninamide, with the CAS number 77128-69-9, is a synthetic peptide that exhibits characteristics typical of peptide compounds. It is composed of multiple amino acids, which contribute to its structural complexity and potential biological activity. The presence of various amino acid residues suggests that it may have specific interactions with biological targets, potentially influencing physiological processes. Peptides like this one can exhibit properties such as solubility in water, stability under certain pH conditions, and susceptibility to enzymatic degradation. Additionally, the presence of N-methyl groups may enhance its metabolic stability and bioavailability. Such compounds are often studied for their roles in drug development, particularly in the fields of therapeutics and biochemistry, where they may serve as signaling molecules or inhibitors. However, detailed studies would be necessary to fully elucidate its pharmacological properties and potential applications in medicine or research.

Formula: C₄₃H₆₁N₉O₉S

InChI: InChI=1/C43H61N9O9S/c1-26(2)22-32(41(59)48-29(38(45)56)20-21-62-5)47-37(55)25-51(3)43(61)34(24-28-14-10-7-11-15-28)52(4)42(60)33(23-27-12-8-6-9-13-27)50-40(58)31(16-18-35(44)53)49-39(57)30-17-19-36(54)46-30/h6-15,26,29-34H,16-25H2,1-5H3,(H2,44,53)(H2,45,56)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,58)/t29-,30-,31-,32-,33-,34-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCSC)C(=N)O)O)N=C(CN(C)C(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)N=C([C@H](CCC(=N)O)N=C([C@@H]1CCC(=N1)O)O)O)O

Synonyms:

• L-methioninamide, 5-oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-
• Pyr-Gln-Phe-N-Me-Phe-Sar-Leu-Met-Nh2
• 5-Oxo-L-prolyl-L-glutaminyl-L-phenylalanyl-N-methyl-L-phenylalanyl-N-methylglycyl-L-leucyl-L-methioninamide

(Pyr 5,N-Me-Phe8, Sar 9)-Substance P (5-11)

CAS: 77128-69-9

Senktide is a substance P analog that has been shown to produce tail-flick responses in animals. The maximum response of the tail-flick test can be enhanced by the administration of either dopamine or serotonin. Inhibition of metabolism is likely to be responsible for these effects, as demonstrated by experiments in Sprague-Dawley rats. Senktide is an experimental model for studying the role of substance P in the regulation of blood pressure and locomotor activity. This compound also has pressor properties that are similar to those of dopamine and serotonin, which may be due to its ability to stimulate alpha-adrenergic receptors and inhibit dopaminergic neurons via a presynaptic mechanism.

Formula: C₄₃H₆₁N₉O₉S

Purity: Min. 95%

Molecular weight: 880.07 g/mol

Ref: 3D-FP109387