CAS 77128-70-2

N-(9-Fluorenylmethoxycarbonyl)-N-methylglycine

Description:

N-(9-Fluorenylmethoxycarbonyl)-N-methylglycine, commonly referred to as Fmoc-N-methylglycine, is a derivative of glycine that is widely used in peptide synthesis and organic chemistry. This compound features a 9-fluorenylmethoxycarbonyl (Fmoc) protective group, which is crucial for the protection of the amino group during peptide synthesis. The presence of the N-methyl group enhances the compound's stability and solubility in organic solvents. Fmoc-N-methylglycine is typically a white to off-white solid and is soluble in common organic solvents such as dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). It is stable under acidic conditions but can be deprotected under basic conditions, allowing for the selective release of the amino group for further reactions. This compound is particularly valuable in solid-phase peptide synthesis, where it facilitates the stepwise assembly of peptides while minimizing side reactions. Its unique structure and properties make it an essential building block in the field of medicinal chemistry and biochemistry.

Formula: C₁₈H₁₇NO₄

InChI: InChI=1S/C18H17NO4/c1-19(10-17(20)21)18(22)23-11-16-14-8-4-2-6-12(14)13-7-3-5-9-15(13)16/h2-9,16H,10-11H2,1H3,(H,20,21)

InChI key: InChIKey=ZHKQIADIIYMFOZ-UHFFFAOYSA-N

SMILES: C(OC(N(CC(O)=O)C)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Synonyms:

• 2-([[(9H-Fluoren-9-yl)methoxy]carbonyl](methyl)amino)acetic acid
• 2-[9H-Fluoren-9-ylmethoxycarbonyl(methyl)amino]acetic acid
• 2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]acetic acid
• 298: PN: US20070042401 PAGE: 38 claimed protein
• 990: PN: WO2006135786 PAGE: 71 claimed protein
• Fmoc-MeGly-OH
• Fmoc-N-methylglycine
• Fmoc-Sar-OH
• Fmoc-Sar-OH monohydrate
• Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-
• N-(9-Fluorenylmethoxycarbonyl)-N-methylglycine

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine

CAS: 77128-70-2

Formula: C₁₈H₁₇NO₄

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 311.34

Ref: 3B-F1163

N-Fmoc-N-methylglycine, 98%

CAS: 77128-70-2

N-Fmoc-N-methylglycine is an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff fields. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may ref

Formula: C₁₈H₁₉NO₅

Purity: 98%

Molecular weight: 329.35

Ref: 02-H62806

Fmoc-Sar-OH

CAS: 77128-70-2

Bachem ID: 4009790.

Formula: C₁₈H₁₇NO₄

Purity: 99.9%

Color and Shape: White

Molecular weight: 311.34

Ref: 01-4009790

Fmoc-Sar-OH

CAS: 77128-70-2

Formula: C₁₈H₁₇NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 311.3319

Ref: IN-DA003SPT

Fmoc-Sar-OH

CAS: 77128-70-2

Formula: C₁₈H₁₇NO₄

Purity: (Titration) ≥ 98.0%

Color and Shape: White to almost white powder

Molecular weight: 311.33

Ref: 7W-GM8696

Fmoc-Sar-OH

CAS: 77128-70-2

Fmoc-Sar-OH

Formula: C₁₈H₁₇NO₄

Purity: 98%

Color and Shape: white to off-white solid

Molecular weight: 311.33g/mol

Ref: 54-OR52600

[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-acetic acid

CAS: 77128-70-2

Formula: C₁₈H₁₇NO₄

Purity: 98%

Color and Shape: Solid, Beige powder

Molecular weight: 311.337

Ref: 10-F021370

Fmoc-N-methylglycine

CAS: 77128-70-2

Fmoc-N-methylglycine is a modified form of the amino acid glycine, which has been modified to include a reactive group that can be used to link other molecules. This molecule has gram-negative bacterial activity and exhibits potent antibacterial activity against many gram-positive bacteria. Fmoc-N-methylglycine is also an antimicrobial peptide with binding constants in the nanomolar range. It is also an agent that binds to serotonin, which may explain its effects on mood and sleep. Fmoc-N-methylglycine can be synthesized using stepwise solid phase synthesis methods or by conjugation with other molecules.

Formula: C₁₈H₁₇NO₄

Purity: Min. 95%

Molecular weight: 311.33 g/mol

Ref: 3D-FF47456