The chemical substance known as (sar9)-substance P, with the CAS number 77128-75-7, is a synthetic analog of the neuropeptide substance P, which is involved in various physiological processes, including pain perception and inflammation. This compound is characterized by its specific amino acid sequence, which includes a substitution at the ninth position with sarcosine (sar), enhancing its stability and receptor affinity compared to natural substance P. (sar9)-substance P exhibits high potency in activating neurokinin receptors, particularly the neurokinin-1 receptor (NK1R), which plays a crucial role in mediating pain and stress responses. Its structural modifications contribute to its pharmacological properties, making it a valuable tool in research related to pain management and neurobiology. Additionally, (sar9)-substance P is often studied for its potential therapeutic applications in conditions such as chronic pain, anxiety, and other neurogenic disorders. As with many peptides, its stability, solubility, and bioavailability are important factors influencing its efficacy in biological systems.

(sar9)-substance-P

77128-75-7: The chemical substance known as (sar9)-substance P, with the CAS number 77128-75-7, is a synthetic analog of the neuropeptide substance P, which is involved in various physiological processes, including pain perception and inflammation. This compound is characterized by its specific amino acid sequence, which includes a substitution at the ninth position with sarcosine (sar), enhancing its stability and receptor affinity compared to natural substance P. (sar9)-substance P exhibits high potency in activating neurokinin receptors, particularly the neurokinin-1 receptor (NK1R), which plays a crucial role in mediating pain and stress responses. Its structural modifications contribute to its pharmacological properties, making it a valuable tool in research related to pain management and neurobiology. Additionally, (sar9)-substance P is often studied for its potential therapeutic applications in conditions such as chronic pain, anxiety, and other neurogenic disorders. As with many peptides, its stability, solubility, and bioavailability are important factors influencing its efficacy in biological systems.

ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET-NH2

[Sar9]-Substance P is one of NK-1 receptor agonist. The action of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.

CAS 77128-75-7

(sar9)-substance-P

ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-SAR-LEU-MET-NH2

Ref: IN-DA00G2OP

[Sar9] Substance P

Ref: TM-TP1862