CAS 77162-51-7
:(R)-Vigabatrin
Description:
(R)-Vigabatrin is a pharmaceutical compound primarily used as an anticonvulsant in the treatment of epilepsy, particularly for patients who do not respond to other medications. It is a derivative of gamma-aminobutyric acid (GABA) and functions as an irreversible inhibitor of the enzyme GABA transaminase, leading to increased levels of GABA in the brain, which helps to stabilize neuronal activity. The compound is characterized by its chiral nature, with the (R) configuration being the active form that exhibits therapeutic effects. Vigabatrin is typically administered orally and is known for its relatively long half-life, allowing for once or twice daily dosing. Common side effects may include drowsiness, dizziness, and potential visual field defects, necessitating regular monitoring of patients. Its chemical structure includes a cyclopropane ring and a carboxylic acid group, contributing to its biological activity. Due to its mechanism of action and efficacy, (R)-Vigabatrin is an important option in the management of refractory epilepsy.
Formula:C6H11NO2
InChI:InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)/t5-/m0/s1
InChI key:InChIKey=PJDFLNIOAUIZSL-YFKPBYRVSA-N
SMILES:[C@@H](CCC(O)=O)(C=C)N
Synonyms:- (-)-γ-Vinyl GABA
- (4R)-4-Amino-5-hexenoic acid
- (R)-4-Aminohex-5-enoic acid
- (R)-Vigabatrin
- 5-Hexenoic acid, 4-amino-, (4R)-
- 5-Hexenoic acid, 4-amino-, (R)-
- Rmi 71894
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