CAS 77174-66-4

Croconazole hydrochloride

Description:

Croconazole hydrochloride is an antifungal agent primarily used in the treatment of various fungal infections. It belongs to the class of imidazole derivatives and exhibits broad-spectrum antifungal activity. The compound is characterized by its ability to inhibit the synthesis of ergosterol, a critical component of fungal cell membranes, thereby disrupting cell membrane integrity and function. Croconazole hydrochloride is typically presented as a white to off-white crystalline powder, which is soluble in water and various organic solvents. Its chemical structure includes a central imidazole ring, contributing to its pharmacological properties. The substance is often formulated in topical preparations, allowing for localized treatment with minimal systemic absorption. Safety and efficacy profiles are established through clinical studies, and like many antifungals, it may have potential side effects, including skin irritation or allergic reactions. Proper handling and storage conditions are essential to maintain its stability and effectiveness.

Formula: C₁₈H₁₆Cl₂N₂O

InChI: InChI=1/C18H15ClN2O.ClH/c1-14(21-10-9-20-13-21)17-7-2-3-8-18(17)22-12-15-5-4-6-16(19)11-15;/h2-11,13H,1,12H2;1H

InChI key: InChIKey=LWJUIYYIILPRRI-UHFFFAOYSA-N

SMILES: C(=C)(C1=C(OCC2=CC(Cl)=CC=C2)C=CC=C1)N3C=CN=C3.Cl

Synonyms:

• 1-[1-[2-[(3-Chlorophenyl)methoxy]phenyl]ethenyl]imidazole hydrochloride
• 1H-Imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]-, hydrochloride (1:1)
• 1H-Imidazole, 1-[1-[2-[(3-chlorophenyl)methoxy]phenyl]ethenyl]-, monohydrochloride
• 710674S
• Croconazole monohydrochloride
• Pilzcin
• Croconazole hydrochloride
• CLOCONAZOL CLORHIDRATO
• CroconazoleHCl
• CLOCONAZOLE HCL