CAS 7722-15-8

Norchlordiazepoxide

Description:

Norchlordiazepoxide, with the CAS number 7722-15-8, is a chemical compound that belongs to the benzodiazepine class of drugs. It is characterized by its psychoactive properties, primarily functioning as an anxiolytic, which means it is used to alleviate anxiety. The compound is known for its sedative and muscle relaxant effects, making it useful in treating various anxiety disorders and related conditions. Structurally, Norchlordiazepoxide is derived from diazepam and features a fused benzodiazepine ring system, which is essential for its pharmacological activity. The compound exhibits a relatively high lipophilicity, allowing it to cross the blood-brain barrier effectively. Its mechanism of action involves the modulation of gamma-aminobutyric acid (GABA) receptors, enhancing the inhibitory effects of GABA neurotransmission in the central nervous system. While it has therapeutic applications, Norchlordiazepoxide can also lead to dependence and withdrawal symptoms, necessitating careful management in clinical settings. As with many benzodiazepines, it is important to monitor for potential side effects and interactions with other medications.

Formula: C₁₅H₁₂ClN₃O

InChI: InChI=1S/C15H12ClN3O/c16-11-6-7-13-12(8-11)15(10-4-2-1-3-5-10)19(20)9-14(17)18-13/h1-8H,9H2,(H2,17,18)

InChI key: InChIKey=LNLMGKOHYYEWMY-UHFFFAOYSA-N

SMILES: O=N1=C(C=2C(N=C(N)C1)=CC=C(Cl)C2)C3=CC=CC=C3

Synonyms:

• 7-Chloro-2-amino-5-phenyl-3H-1,4-benzodiazepine 4-oxide
• 3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-phenyl-, 4-oxide
• 3H-1,4-Benzodiazepine, 2-amino-7-chloro-5-phenyl-, 4-oxide
• N-Demethylchlordiazepoxide
• Demethylchlordiazepoxide

N-Demethyl Chlordiazepoxide

Controlled Product

CAS: 7722-15-8

Applications The main metabolite of Chlordiazepoxide (C327050).
References Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002);

Formula: C₁₅H₁₂ClN₃O

Color and Shape: Off-White To Light Yellow

Molecular weight: 285.73

Ref: TR-D230825

N-Demethyl Chlordiazepoxide (1 mg/mL in 20% DMSO in Acetonitrile)

Controlled Product

CAS: 7722-15-8

Formula: C₁₅H₁₂ClN₃O

Color and Shape: Colourless

Molecular weight: 285.73

Ref: TR-KIT1725

N-Demethyl Chlordiazepoxide-d5

Controlled Product

CAS: 7722-15-8

Applications N-Demethyl Chlordiazepoxide-d5 is the deuterium labelled analogue of N-Demethyl Chlordiazepoxide (D230825), which is the main metabolite of anxiolytic drug Chlordiazepoxide (C327050).
References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978); Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002);

Formula: C₁₅H₇D₅ClN₃O

Color and Shape: Off-White To Light Yellow

Molecular weight: 290.76

Ref: TR-D230827

N-Demethyl Chlordiazepoxide-d5 (1mg/ml in Acetonitrile)

Controlled Product

CAS: 7722-15-8

Formula: C₁₅H₇D₅ClN₃O

Color and Shape: Single Solution

Molecular weight: 290.76

Ref: TR-KIT3960

2-Amino-7-chloro-5-phenyl-3H-benzo[e][1,4]diazepine 4-oxide

CAS: 7722-15-8

Formula: C₁₅H₁₂ClN₃O

Molecular weight: 285.73

Ref: ST-EA-CP-D18019