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CAS 77222-61-8

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5-[(E)-2-bromoethenyl]-2'-deoxyuridine 5'-(tetrahydrogen triphosphate)

Description:
5-[(E)-2-bromoethenyl]-2'-deoxyuridine 5'-(tetrahydrogen triphosphate), commonly referred to as BrdUTP, is a modified nucleotide that incorporates a bromovinyl group at the 5-position of the uridine base. This compound is characterized by its ability to act as a substrate for DNA polymerases, allowing it to be incorporated into DNA during replication or repair processes. The presence of the bromovinyl group enhances its reactivity and can influence the biological activity of the resulting DNA. BrdUTP is often utilized in molecular biology applications, such as in situ hybridization and labeling experiments, due to its ability to be detected using specific antibodies or fluorescent probes. The triphosphate moiety provides the necessary energy for incorporation into nucleic acids, making it a valuable tool in research involving DNA synthesis and modification. Additionally, its unique structure allows for the study of DNA dynamics and interactions, contributing to our understanding of nucleic acid biochemistry.
Formula:C11H16BrN2O14P3
InChI:InChI=1/C11H16BrN2O14P3/c12-2-1-6-4-14(11(17)13-10(6)16)9-3-7(15)8(26-9)5-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,4,7-9,15H,3,5H2,(H,21,22)(H,23,24)(H,13,16,17)(H2,18,19,20)/b2-1+/t7-,8+,9+/m0/s1
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