CAS 7728-73-6

(E,Z)-Tamoxifen

Description:

(E,Z)-Tamoxifen is a synthetic compound primarily used in the treatment and prevention of estrogen receptor-positive breast cancer. It is classified as a selective estrogen receptor modulator (SERM), which means it can act as an estrogen antagonist in breast tissue while exhibiting estrogen-like effects in other tissues, such as bone and endometrium. The compound features a biphenyl structure with a trans (E) and cis (Z) configuration, which contributes to its biological activity. (E,Z)-Tamoxifen is known for its ability to bind to estrogen receptors, inhibiting the proliferation of estrogen-dependent tumors. Its pharmacokinetics include oral bioavailability, and it undergoes extensive hepatic metabolism, primarily by cytochrome P450 enzymes, leading to the formation of active metabolites. Common side effects may include hot flashes, nausea, and an increased risk of thromboembolic events. Overall, (E,Z)-Tamoxifen remains a cornerstone in breast cancer therapy, demonstrating both efficacy and a unique mechanism of action in hormone-sensitive malignancies.

Formula: C₂₆H₂₉NO

InChI: InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3

InChI key: InChIKey=NKANXQFJJICGDU-UHFFFAOYSA-N

SMILES: C(=C(CC)C1=CC=CC=C1)(C2=CC=C(OCCN(C)C)C=C2)C3=CC=CC=C3

Synonyms:

• 2-[4-(1,2-Diphenyl-1-buten-1-yl)phenoxy]-N,N-dimethylethanamine
• Ethanamine, 2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-
• Ethylamine, 2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethyl-
• 1-[p-[2-(N,N-Dimethylamino)ethoxy] phenyl]-1,2-diphenylbut-1-ene
• Ethanamine, 2-[4-(1,2-diphenyl-1-buten-1-yl)phenoxy]-N,N-dimethyl-

(E/Z)Tamoxifen

CAS: 7728-73-6

Formula: C₂₆H₂₉NO

Molecular weight: 371.52

Ref: 4Z-T-0121

(E/Z)-Tamoxifen-d5

Controlled Product

CAS: 7728-73-6

Applications Mixture of labelled Tamoxifen and its (E)-isomer.

Formula: C₂₆H₂₄D₅NO

Color and Shape: Off White Solid

Molecular weight: 376.55

Ref: TR-T006007