CAS 77307-50-7

Kaempferol 3-O-(3′′,4′′-di-O-acetyl-α-L-rhamnopyranoside)

Description:

Kaempferol 3-O-(3′′,4′′-di-O-acetyl-α-L-rhamnopyranoside) is a flavonoid glycoside, a subclass of flavonoids known for their antioxidant properties. This compound features a kaempferol backbone, which is a flavonol, and is modified by the presence of a rhamnose sugar moiety that is further acetylated at two positions. The acetylation enhances its solubility and stability, potentially influencing its biological activity. Kaempferol derivatives are often studied for their potential health benefits, including anti-inflammatory, anticancer, and cardioprotective effects. The presence of the rhamnopyranoside unit may also contribute to its bioactivity and interaction with biological systems. This compound is typically found in various plants, particularly in fruits and vegetables, and is of interest in pharmacognosy and natural product chemistry. Its CAS number, 77307-50-7, allows for precise identification in chemical databases and literature. Overall, kaempferol 3-O-(3′′,4′′-di-O-acetyl-α-L-rhamnopyranoside) exemplifies the complex interplay between structure and function in natural products.

Formula: C₂₅H₂₄O₁₂

InChI: InChI=1/C25H24O12/c1-10-21(34-11(2)26)24(35-12(3)27)20(32)25(33-10)37-23-19(31)18-16(30)8-15(29)9-17(18)36-22(23)13-4-6-14(28)7-5-13/h4-10,20-21,24-25,28-30,32H,1-3H3/t10-,20+,21?,24?,25?/m0/s1

InChI key: InChIKey=SXOZSDJHGMAEGZ-IGKKHSBFSA-N

SMILES: O(C1=C(OC=2C(C1=O)=C(O)C=C(O)C2)C3=CC=C(O)C=C3)[C@H]4[C@H](O)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H](C)O4

Synonyms:

• 3-[(3,4-Di-O-acetyl-6-deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• 3′′,4′′-Di-O-acetylafzelin
• 4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-<span class="text-smallcaps">L</span>-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
• Kaempferol 3-O-(3′′,4′′-di-O-acetyl-α-<span class="text-smallcaps">L</span>-rhamnopyranoside)
• Sl 0101
• Sl 0101-1
• Sl0101
• 4H-1-Benzopyran-4-one, 3-[(3,4-di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
• 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Kaempferol 3-O-(3′′,4′′-di-O-acetyl-α-L-rhamnopyranoside)
• 2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside
• 2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one
• 3'',4''-Di-O-acetylafzelin
• Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside)
• 3-[(3,4-Di-O-acetyl-6-deoxy-α-L-mannopyranosyl)oxy]-5,7-dihydro-2-(4-hydroxyphenyl)-4H-1benzopyran-4-one
• 3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone

SL 0101-1

CAS: 77307-50-7

SL0101: selective, reversible ATP-competitive RSK inhibitor, membrane-permeable, IC50=89nM, potent RSK1/2 inhibitor, Ki=1μM.

Formula: C₂₅H₂₄O₁₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 516.45

Ref: TM-T16896

Sl0101

CAS: 77307-50-7

Sl0101

Molecular weight: 516.45085g/mol

Ref: 54-BISN0307

SL0101

Controlled Product

CAS: 77307-50-7

Applications SL 0101 is a potent and selective inhibitor of p90 Rsk, without inhibiting the function of upstream kinases such as MEK, Raf, or PKC.
References Maloney, D.J. and Hecht, S.M.: Organic Letters, 7, 6, 1097 (2005)

Formula: C₂₅H₂₄O₁₂

Color and Shape: Neat

Molecular weight: 516.45

Ref: TR-S560000

SL 0101-1

CAS: 77307-50-7

SL 0101-1 is a transcriptional regulator that regulates the expression of genes and proteins. It belongs to the family of inhibitors, which are pharmacological agents that inhibit the activity of other drugs or enzymes. This compound is an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). These enzymes regulate cellular processes such as cell growth, differentiation, and survival. SL 0101-1 has been shown to induce mitochondrial membrane depolarization, neuronal death, and inhibition of DNA polymerase activity in cancer tissues. In addition, it inhibits the binding of a nuclear factor to DNA and phosphorylation in neuronal cells. SL 0101-1 also has anti-inflammatory properties by inhibiting cyclooxygenase-2 (COX-2), which is responsible for production of prostaglandins.

Formula: C₂₅H₂₄O₁₂

Purity: Min. 95%

Molecular weight: 516.46 g/mol

Ref: 3D-CDA30750