CAS 77326-96-6

Flunisolide Hemihydrate

Description:

Flunisolide hemihydrate is a synthetic corticosteroid primarily used for its anti-inflammatory properties, particularly in the treatment of respiratory conditions such as asthma and allergic rhinitis. It is characterized by its ability to inhibit the release of inflammatory mediators, thereby reducing inflammation and associated symptoms. The substance appears as a white to off-white crystalline powder and is soluble in organic solvents like ethanol and methanol, but has limited solubility in water due to its hemihydrate form. Flunisolide hemihydrate has a molecular formula that reflects its complex structure, which includes a steroid backbone modified with various functional groups that enhance its pharmacological activity. The hemihydrate form indicates that it contains a specific amount of water in its crystalline structure, which can influence its stability and solubility. As with many corticosteroids, it is essential to use flunisolide hemihydrate under medical supervision to manage potential side effects and ensure appropriate dosing.

Formula: C₄₈H₆₄F₂O₁₃

InChI: InChI=1/2C24H31FO6.H2O/c2*1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26;/h2*5-7,13-14,16-17,19-20,26,28H,8-11H2,1-4H3;1H2/t2*13-,14-,16-,17-,19+,20+,22-,23-,24+;/m00./s1

Synonyms:

• Flunisolide [INN]
• Flunisolide
• Aerobid
• Aerobid M
• Aerospan
• Aerospan HFA
• Bronalide
• Flunisolida
• Flunisolida [INN-Spanish]
• Flunisolide HFA
• Flunisolidum
• Flunisolidum [INN-Latin]
• Lunis
• Nasalide
• Nasarel
• Nisolid
• Rs 3999
• Rhinalar
• Soluzione
• Synaclyn
• Syntaris
• Unii-78M02Aa8Kf
• 6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16, 17-acetal with acetone
• Pregna-1,4-diene-3,20-dione, 6-alpha-fluoro-11-beta,16-alpha,17,21-tetrahydroxy-, cyclic 16,17-acetal with acetone
• Pregna-1,4-diene-3,20-dione, 6-fluoro-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-, (6alpha,11beta,16alpha)-
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (6bS,9aR,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (4aR,5S,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one
• (4aR,4bS,5S,6aS,6bS,9aR,10aS,10bS,12S)-12-fluoro-5-hydroxy-6b-(hydroxyacetyl)-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one hydrate (2:1)

Flunisolide

CAS: 77326-96-6

Halogenated derivatives of adrenal cortical hormones

Formula: C₂₄H₃₁FO₆H₂O

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 434.21047

Ref: 45-1274505

Flunisolide Hemihydrate

Controlled Product

CAS: 77326-96-6

Formula: C₂₄H₃₁FO₆·H₂O

Color and Shape: Neat

Molecular weight: 887.01

Ref: 86-MM0379.00

Flunisolide

Controlled Product

CAS: 77326-96-6

Applications Flunisolide is a synthetic fluorinated corticosteroid related to Prednisolone (P703740). Antiasthmatic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chu, N.I., et al.: Drug Metab. Dispos., 7, 81 (1979), Pakes, G.E., et al.: Drugs, 19, 397 (1980)

Formula: C₂₄H₃₁FO₆

Color and Shape: White To Light Yellow

Molecular weight: 887.01

Ref: TR-F500485

Flunisolide hemihydrate

CAS: 77326-96-6

Flunisolide hemihydrate, a corticosteroid with anti-inflammatory properties, treats asthma and rhinitis by inducing eosinophil apoptosis.

Formula: C₄₈H₆₄F₂O₁₃

Color and Shape: Solid

Molecular weight: 887.024

Ref: TM-T62604