CAS 77360-52-2

Ceftiolene

Description:

Ceftiolene, identified by its CAS number 77360-52-2, is a synthetic antibiotic belonging to the cephalosporin class of beta-lactam antibiotics. It is primarily used for its antibacterial properties, effective against a range of Gram-positive and Gram-negative bacteria. Ceftiolene works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. This compound is characterized by its stability against certain beta-lactamases, which are enzymes produced by bacteria that can inactivate many antibiotics. Ceftiolene is typically administered via injection and is utilized in treating various infections, including those of the respiratory tract, skin, and soft tissues. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion, which are crucial for determining dosing regimens. As with other antibiotics, the potential for resistance development necessitates careful use and adherence to prescribed guidelines. Overall, ceftiolene represents an important option in the arsenal against bacterial infections, particularly in cases where other antibiotics may be ineffective.

Formula: C₂₀H₁₈N₈O₈S₃

InChI: InChI=1/C20H18N8O8S3/c1-36-26-10(9-7-39-19(21)22-9)13(30)23-11-15(32)28-12(18(34)35)8(6-38-17(11)28)2-5-37-20-25-24-14(31)16(33)27(20)3-4-29/h2,4-5,7,11,17H,3,6H2,1H3,(H2,21,22)(H,23,30)(H,24,31)(H,34,35)/b5-2+,26-10-/t11-,17-/m1/s1

InChI key: InChIKey=WJXAHFZIHLTPFR-JLRJEBFFSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C3=CSC(N)=N3)=O)C2=O)(SCC1/C=C/SC=4N(CC=O)C(=O)C(=O)NN4)[H]

Synonyms:

• (6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-3-((E)-2-((4-(formylmethyl)-1,4,5,6-tetrahydro-5,6-dioxo-as-triazin-3-yl)thio)vinyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid 7(sup 2)-(Z)-(O-methyloxime)
• (6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[(1E)-2-[[1,4,5,6-tetrahydro-5,6-dioxo-4-(2-oxoethyl)-1,2,4-triazin-3-yl]thio]ethenyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[2-[[1,4,5,6-tetrahydro-5,6-dioxo-4-(2-oxoethyl)-1,2,4-triazin-3-yl]thio]ethenyl]-, [6R-[3(E),6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-8-oxo-3-[(1E)-2-[[1,4,5,6-tetrahydro-5,6-dioxo-4-(2-oxoethyl)-1,2,4-triazin-3-yl]thio]ethenyl]-, (6R,7R)-
• Cefathiolene
• Cefatiolene
• Ceftiolene [INN]
• Ceftiolenum
• Ceftiolenum [Latin]
• Rp 42980
• Unii-28Tv2P33Kf
• Ceftiolene