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CAS 77377-52-7

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N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide

Description:
N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide, with the CAS number 77377-52-7, is a chemical compound commonly used in organic synthesis and analytical chemistry, particularly in the derivatization of amines and alcohols for gas chromatography. This compound features a trifluoroacetamide functional group, which enhances volatility and thermal stability, making it suitable for gas-phase analysis. The presence of the tert-butyldimethylsilyl group provides steric protection and increases the lipophilicity of the molecule, facilitating the separation and detection of target analytes. N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide is typically a colorless to pale yellow liquid with a characteristic odor. It is soluble in organic solvents and is stable under standard laboratory conditions. However, like many silyl derivatives, it may hydrolyze in the presence of moisture, releasing silyl alcohols. Safety precautions should be taken when handling this compound, as it may pose health risks if inhaled or ingested. Proper storage in a cool, dry place is recommended to maintain its integrity.
Formula:C9H18F3NOSi
InChI:InChI=1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3
InChI key:InChIKey=QRKUHYFDBWGLHJ-UHFFFAOYSA-N
SMILES:N([Si](C(C)(C)C)(C)C)(C(C(F)(F)F)=O)C
Synonyms:
  • Acetamide, N-[(1,1-dimethylethyl)dimethylsilyl]-2,2,2-trifluoro-N-methyl-
  • N-(Tertbutyldimethylsilyl)-N-methyltrifluoroacetamide
  • N-(t-butyldimethylsilyl)-N-Methyl-trifluoroacetamide
  • N-Methyl-N-(tert-butyldimethylsilyl)-1,1,1-trifluoroacetamide
  • N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide
  • N-Methyl-N-(tert-butyltdimethylsilyl)trifluoroacetamide
  • N-[(1,1-Dimethylethyl)dimethylsilyl]-2,2,2-trifluoro-N-methylacetamide
  • N-[butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide
  • N-methyl-N-(t-butyldimethylsilyl)trifluoroacetamide
  • N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide
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