CAS 77377-52-7

N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide

Description:

N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide, with the CAS number 77377-52-7, is a chemical compound commonly used in organic synthesis and analytical chemistry, particularly in the derivatization of amines and alcohols for gas chromatography. This compound features a trifluoroacetamide functional group, which enhances volatility and thermal stability, making it suitable for gas-phase analysis. The presence of the tert-butyldimethylsilyl group provides steric protection and increases the lipophilicity of the molecule, facilitating the separation and detection of target analytes. N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide is typically a colorless to pale yellow liquid with a characteristic odor. It is soluble in organic solvents and is stable under standard laboratory conditions. However, like many silyl derivatives, it may hydrolyze in the presence of moisture, releasing silyl alcohols. Safety precautions should be taken when handling this compound, as it may pose health risks if inhaled or ingested. Proper storage in a cool, dry place is recommended to maintain its integrity.

Formula: C₉H₁₈F₃NOSi

InChI: InChI=1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

InChI key: InChIKey=QRKUHYFDBWGLHJ-UHFFFAOYSA-N

SMILES: N([Si](C(C)(C)C)(C)C)(C(C(F)(F)F)=O)C

Synonyms:

• Acetamide, N-[(1,1-dimethylethyl)dimethylsilyl]-2,2,2-trifluoro-N-methyl-
• N-(Tertbutyldimethylsilyl)-N-methyltrifluoroacetamide
• N-(t-butyldimethylsilyl)-N-Methyl-trifluoroacetamide
• N-Methyl-N-(tert-butyldimethylsilyl)-1,1,1-trifluoroacetamide
• N-Methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide
• N-Methyl-N-(tert-butyltdimethylsilyl)trifluoroacetamide
• N-[(1,1-Dimethylethyl)dimethylsilyl]-2,2,2-trifluoro-N-methylacetamide
• N-[butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide
• N-methyl-N-(t-butyldimethylsilyl)trifluoroacetamide
• N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide

CAS: 77377-52-7

Formula: C₉H₁₈F₃NOSi

Purity: >95.0%(GC)

Color and Shape: Colorless to Almost colorless clear liquid

Molecular weight: 241.33

Ref: 3B-B1150

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide, 97%

CAS: 77377-52-7

It finds its application in the preparation of N-tert-butyldimethylsilyl ethanolamines resulting from hydrolysis of nitrogen mustards and a silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatography-mass spectrometry (GC-MS) analysis and sel

Formula: C₉H₁₈F₃NOSi

Purity: 97%

Color and Shape: Clear colorless to pale yellow, Liquid

Molecular weight: 241.33

Ref: 02-B23760

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

CAS: 77377-52-7

Formula: C₉H₁₈F₃NOSi

Purity: 95%

Color and Shape: Liquid

Molecular weight: 241.3260

Ref: IN-DA0036J3

N-[(tert-Butyl)dimethylsilyl]-N-methyltrifluoroacetamide

CAS: 77377-52-7

N-[(tert-Butyl)dimethylsilyl]-N-methyltrifluoroacetamide

Formula: C₉H₁₈F₃NOSi

Purity: 98%

Color and Shape: clear. colourless liquid

Molecular weight: 241.33g/mol

Ref: 54-PC5157

N-(tert-Butyldimethylsilyl)-N-methyl trifluoroacetamide

CAS: 77377-52-7

Formula: C₉H₁₈F₃NOSi

Purity: ≥ 96.0%

Color and Shape: Clear, colourless liquid

Molecular weight: 241.33

Ref: 7W-GK4999

N-[(tert-Butyl)dimethylsilyl]-N-methyltrifluoroacetamide

CAS: 77377-52-7

N-[(tert-Butyl)dimethylsilyl]-N-methyltrifluoroacetamide

Formula: C₉H₁₈F₃NOSi

Purity: 95%

Color and Shape: clear. almost colourless liquid

Molecular weight: 241.32602g/mol

Ref: 54-PC0406

N-Methyl-N-(tert-butyldimethylsilyl)trifluoro-acetamide

CAS: 77377-52-7

S11050 - N-Methyl-N-(tert-butyldimethylsilyl)trifluoro-acetamide

Formula: C₉H₁₈F₃NOSi

Purity: 95%

Color and Shape: Liquid, Clear

Molecular weight: 241.329

Ref: 10-S11050

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide (Technical Grade)

CAS: 77377-52-7

Applications A silylating agent used in the derivatization of various organic compounds (such as amino acids) for gas chromatogography-mass spectrometry (GC-MS) analysis.
References Pleasance, S. et al.: Biomed. Env. Mass Spec., 19, 420 (1990); Paik, M. et al.: BMB Rep., 41, 23 (2008);

Formula: C₉H₁₈F₃NOSi

Color and Shape: Neat

Molecular weight: 241.33

Ref: TR-B691310

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide

CAS: 77377-52-7

N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide is an analytical method for measuring the concentration of hydrogen fluoride in human serum. It is used as a reagent to extract metabolic compounds from wastewater and to measure the quantity of chlorogenic acids in plant leaves. This compound is also used as a reagent for gas chromatography/mass spectrometry analysis of the aromatic amines, which are carcinogens. N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide has been shown to inhibit proliferation of HL-60 cells, which are derived from a myeloid leukemia cell line, and colon cancer cell lines. This compound has been shown to be effective against colon cancer cells through its ability to induce apoptosis.

Formula: C₉H₁₈F₃NOSi

Purity: Min. 97%

Color and Shape: Colorless Clear Liquid

Molecular weight: 241.33 g/mol

Ref: 3D-FB19530