CAS 77439-76-0

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone

Description:

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone, with the CAS number 77439-76-0, is a synthetic organic compound characterized by its furanone structure, which includes a furan ring with various substituents. This compound features a chlorine atom at the 3-position, a dichloromethyl group at the 4-position, and a hydroxyl group at the 5-position of the furanone ring. The presence of these functional groups contributes to its reactivity and potential applications in various chemical processes. It is known for its role in the synthesis of other chemical entities and may exhibit biological activity, making it of interest in pharmaceutical research. The compound is typically handled with care due to its halogenated nature, which can impart toxicity and environmental concerns. As with many furanones, it may also participate in reactions such as nucleophilic substitutions or cycloadditions, depending on the reaction conditions and the presence of other reagents. Proper safety measures should be observed when working with this compound in laboratory settings.

Formula: C₅H₃Cl₃O₃

InChI: InChI=1S/C5H3Cl3O3/c6-2-1(3(7)8)4(9)11-5(2)10/h3-4,9H

InChI key: InChIKey=WNTRMRXAGJOLCU-UHFFFAOYSA-N

SMILES: C(Cl)(Cl)C1=C(Cl)C(=O)OC1O

Synonyms:

• 2(5H)-Furanone, 3-chloro-4-(dichloromethyl)-5-hydroxy-
• 3-Chloro-4-(dichloromethyl)-5-hydroxy-2,5-dihydrofuran-2-one
• 3-chloro-4-(dichloromethyl)-5-hydroxy-*2(5H)-fura
• MX (bacterial mutagen)
• Mutagen X
• 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone
• MX

3-Chloro-4-(dichloromethyl)-5-hydroxyfuran-2(5H)-one

CAS: 77439-76-0

Formula: C₅H₃Cl₃O₃

Color and Shape: Liquid

Molecular weight: 217.4345

Ref: IN-DA005LLO

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone

Controlled Product

CAS: 77439-76-0

Applications Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),

Formula: C₅H₃Cl₃O₃

Color and Shape: Neat

Molecular weight: 217.43

Ref: TR-C365665

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone

CAS: 77439-76-0

3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone belongs to the class of polymerase chain inhibitors. It inhibits DNA synthesis by binding to the enzyme DNA polymerase and blocking the progression of DNA synthesis. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone has significant cytotoxicity in mammalian cells and is genotoxic, which may be due to its mutagenicity. The mechanism of its mutagenicity is not known, but it has been shown that this compound reacts with effector proteins such as thiols and sulfhydryls. 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone can react with chlorine in water to form a chlorinated derivative that is more stable than the parent compound. This chemical stability has been used

Formula: C₅H₃Cl₃O₃

Purity: (%) Min. 95%

Color and Shape: Powder

Molecular weight: 217.43 g/mol

Ref: 3D-FC20076