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CAS 77449-94-6

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(2R,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid hydrochloride

Description:
(2R,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acid hydrochloride, commonly known as L-Proline hydrochloride, is an amino acid derivative characterized by its cyclic structure, which includes a five-membered pyrrolidine ring. This compound features a hydroxyl group and a carboxylic acid functional group, contributing to its solubility in water and its role in biological systems. It is a chiral molecule, with specific stereochemistry denoted by the (2R,4R) configuration, which is crucial for its biological activity. As a hydrochloride salt, it is typically more stable and easier to handle than its free base form. This compound is often utilized in peptide synthesis and as a building block in organic chemistry due to its ability to participate in various reactions, including nucleophilic attacks and cyclization processes. Additionally, it has applications in pharmaceuticals and biochemistry, particularly in the synthesis of proline-rich peptides and proteins. Its safety profile is generally favorable, but standard laboratory precautions should be observed when handling it.
Formula:C5H10ClNO3
InChI:InChI=1/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/m1./s1
SMILES:C1[C@H](CN[C@H]1C(=O)O)O.Cl
Synonyms:
  • (4R)-4-Hydroxy-D-proline hydrochloride (1:1)
  • D-proline, 4-hydroxy-, (4R)-, hydrochloride (1:1)
  • cis-4-Hydroxy-D-proline hydrochloride
  • cis-D-Hyp-OH.HCl
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