CAS 774538-96-4

cis-Montelukast

Description:

Cis-Montelukast, identified by its CAS number 774538-96-4, is a chemical compound that serves as a leukotriene receptor antagonist. It is primarily used in the management of asthma and allergic rhinitis by inhibiting the action of leukotrienes, which are inflammatory mediators that contribute to bronchoconstriction and mucus production. The "cis" designation refers to the specific geometric configuration of the molecule, which can influence its biological activity and interaction with receptors. Cis-Montelukast is typically administered orally and is known for its favorable pharmacokinetic profile, including good oral bioavailability and a long half-life, allowing for once-daily dosing. The compound is generally well-tolerated, with a side effect profile that may include headache, gastrointestinal disturbances, and, in rare cases, mood changes. Its efficacy in reducing asthma symptoms and improving lung function makes it a valuable therapeutic option in respiratory medicine. As with any medication, it is important for patients to consult healthcare professionals for personalized advice and management.

Formula: C₃₅H₃₆ClNO₃S

Synonyms:

• 1-[[[(1R)-1-[3-[(1Z)-2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid

Z-Montelukast ([1-[[[(1R)-1-[3-[(Z)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic acid)

CAS: 774538-96-4

Compounds containing a quinoline or isoquinoline ring-system, whether or not hydrogenated, not further fused, excluding drugs and pesticides

Formula: C₃₅H₃₆ClNO₃S

Color and Shape: Yellow Pale Yellow Solid

Molecular weight: 585.21044

Ref: 45-1A07170

Montelukast EP Impurity G (cis-Montelukast)

CAS: 774538-96-4

Formula: C₃₅H₃₆ClNO₃S

Color and Shape: Off-White Solid

Molecular weight: 586.19

Ref: 4Z-M-3011

[1-[[[(1R)-1-[3-[(Z)-2-(7-Chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropyl]acetic Acid

CAS: 774538-96-4

Color and Shape: Neat

Ref: 86-MM0698.13

Montelukast EP impurity G

CAS: 774538-96-4

Formula: C₃₅H₃₆ClNO₃S

Molecular weight: 586.18

Ref: ST-EA-CP-M25007

cis-Montelukast

Controlled Product

CAS: 774538-96-4

Impurity Montelukast EP Impurity G; Montelukast USP Related Compound G; Montelukast Cis-Isomer
Stability Light Sensitive
Applications cis-Montelukast (Montelukast EP Impurity G; Montelukast USP Related Compound G; Montelukast cis Isomer) is a cis geometric isomer of Montelukast. An impurity of Montelukast.
References Schoors, D., et al.: Br. J. Clin. Pharmacol., 40, 277 (1995), Amin, R., et al.: J. Pharm. Biomed. Anal., 13, 155 (1995), Reiss, T., et al.: J. Allergy Clin. Immunol., 98, 528 (1996),

Formula: C₃₅H₃₆ClNO₃S

Color and Shape: Light Yellow

Molecular weight: 586.18

Ref: TR-M568005

cis-Montelukast

CAS: 774538-96-4

Montelukast is a beta-adrenergic receptor antagonist that blocks the binding of leukotrienes to their receptors, resulting in decreased airway inflammation and obstruction. It is used for the prevention and treatment of asthma, chronic obstructive pulmonary disease (COPD), and allergic rhinitis. The efficiency of this drug has been shown in experiments with nifedipine, which is a calcium channel blocker. Montelukast is sensitive to light, which may change its structure. This drug also binds to clavulanic acid, an inhibitor of beta-lactamase enzymes found in some bacteria. This interaction prevents the breakdown of clavulanic acid by these enzymes and increases its antibacterial activity. Montelukast can be quantified using UV absorption spectroscopy or HPLC methods. These methods are more specific than UV spectroscopy because they can measure both cis-montelukast and trans-montelukast equally well.

Formula: C₃₅H₃₆ClNO₃S

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 586.18 g/mol

Ref: 3D-FM26070