CAS 775-11-1

N-Nitroso-N-(phenylmethyl)urea

Description:

N-Nitroso-N-(phenylmethyl)urea, with the CAS number 775-11-1, is a chemical compound that belongs to the class of nitrosoureas, which are known for their potential as alkylating agents. This compound is characterized by the presence of a nitroso group (-N=O) attached to a urea structure, specifically modified with a phenylmethyl group. It is typically a white to pale yellow solid that is soluble in organic solvents. N-Nitroso-N-(phenylmethyl)urea is of interest in both medicinal chemistry and toxicology due to its ability to induce DNA damage, which can lead to mutagenic and carcinogenic effects. As a result, it is often studied for its implications in cancer research and the mechanisms of chemical carcinogenesis. Handling this compound requires caution due to its potential health hazards, and it is typically managed under strict laboratory safety protocols. Its reactivity and biological effects make it a significant subject of study in the fields of pharmacology and environmental health.

Formula: C₈H₉N₃O₂

InChI: InChI=1S/C8H9N3O2/c9-8(12)11(10-13)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,12)

InChI key: InChIKey=HBOGKXXMRLVGFX-UHFFFAOYSA-N

SMILES: C(N(C(N)=O)N=O)C1=CC=CC=C1

Synonyms:

• N-Benzyl-N-nitrosourea
• N-Nitroso-N-(phenylmethyl)urea
• N-Nitroso-N-benzylurea
• N-Nitrosobenzylurea
• NSC 67523
• Urea, 1-benzyl-1-nitroso-
• urea, N-nitroso-N-(phenylmethyl)-

1-Benzyl-1-nitrosourea

CAS: 775-11-1

1-Benzyl-1-nitrosourea is a nitrosourea alkylating agent that induces DNA methylation. It is hepatotoxic and carcinogenic in rats, but not in mice. This drug does not cause DNA methylation at high substrate concentrations, but does so at low concentrations. The carcinogenic effects of this drug have been observed in the liver, mammary glands, and other tissues. The carcinogenic activity of 1-Benzyl-1-nitrosourea has been shown to be dependent on the strain of animal used and the dose administered.

Formula: C₈H₉N₃O₂

Purity: Min. 95%

Molecular weight: 179.18 g/mol

Ref: 3D-AAA77511