CAS 7753-60-8

Anecortave

Description:

Anecortave, identified by the CAS number 7753-60-8, is a synthetic compound primarily studied for its potential therapeutic applications, particularly in the field of ophthalmology. It is a derivative of the corticosteroid family, designed to exert anti-inflammatory effects while minimizing systemic side effects. Anecortave functions by inhibiting angiogenesis, the process through which new blood vessels form, which is particularly relevant in conditions such as age-related macular degeneration. The compound is characterized by its ability to modulate immune responses and reduce inflammation without the typical side effects associated with traditional corticosteroids. Its formulation is typically administered via injection, allowing for localized treatment with reduced systemic exposure. Research into anecortave has focused on its efficacy, safety profile, and optimal delivery methods, making it a subject of interest in ongoing clinical studies. As with any pharmaceutical agent, understanding its pharmacokinetics, mechanism of action, and potential interactions with other medications is crucial for its effective application in clinical settings.

Formula: C₂₃H₃₀O₅

InChI: InChI=1S/C23H30O5/c1-14(24)28-13-20(26)23(27)11-8-19-17-5-4-15-12-16(25)6-9-21(15,2)18(17)7-10-22(19,23)3/h7,12,17,19,27H,4-6,8-11,13H2,1-3H3/t17-,19+,21+,22+,23+/m1/s1

InChI key: InChIKey=YUWPMEXLKGOSBF-GACAOOTBSA-N

SMILES: C[C@@]12[C@]([C@]3(C([C@]4(C)C(CC3)=CC(=O)CC4)=CC1)[H])(CC[C@@]2(C(COC(C)=O)=O)O)[H]

Synonyms:

• 17-Alpha,21-Dihydroxypregna-4,9(11)-Diene-3,20-Dione21-Acetate
• 17-Hydroxy-3,20-Dioxopregna-4,9(11)-Dien-21-Yl Acetate
• 17-Hydroxypregna-4,9(11)-diene-3,20-dione-21-acetate
• 2-((10S,13S,17R)-17-Hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,10,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
• 21-(Acetyloxy)-17-hydroxypregna-4,9(11)-diene-3,20-dione
• 21-Acetoxypregna-4,9(11)-dien-17α-ol-3,20-dione
• Al 3789
• Anecortave
• Anecortave Acetate
• Anecortave Acetate (200 MG)F0E2980.997MG/MG(AI)
• NSC 15475
• NSC 24345
• Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate
• Pregna-4,9(11)-diene-3,20-dione, 17,21-dihydroxy-, 21-acetate
• Pregna-4,9(11)-diene-3,20-dione, 21-(acetyloxy)-17-hydroxy-
• Retaane

ANECORTAVE ACETATE F0E2980.997MG/MG(AI)

CAS: 7753-60-8

Formula: C₂₃H₃₀O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 386.4813

Ref: IN-DA00G4C2

Anecortave Acetate

CAS: 7753-60-8

Anecortave Acetate

Purity: ≥98%

Molecular weight: 386.48g/mol

Ref: 54-BUP06578

Anecortave Acetate

CAS: 7753-60-8

Anecortave Acetate

Purity: 98%

Molecular weight: 386.48g/mol

Ref: 54-OR1026616

Anecortave Acetate

CAS: 7753-60-8

Formula: C₂₃H₃₀O₅

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 386.49

Ref: 3B-A3649

Anecortave Acetate (δ-9(11)-Hydrocortisone Acetate, Hydrocortisone Acetate EP Impurity E)

CAS: 7753-60-8

Formula: C₂₃H₃₀O₅

Molecular weight: 386.49

Ref: 4Z-A-123001

Anecortave Acetate

CAS: 7753-60-8

Anecortave Acetate (NSC-24345), an angiostatic steroid, is used for proteomics research.

Formula: C₂₃H₃₀O₅

Purity: 99.88%

Color and Shape: Solid

Molecular weight: 386.48

Ref: TM-T21452

Anecortave

CAS: 7753-60-8

Impurity Hydrocortisone Acetate EP Impurity E
Applications Anecortave (Hydrocortisone Acetate EP Impurity E) is an angiostatic steroid. Used in treatment of macular degeneration.
References Clark, A.F., et al.: Expert Opin. Invest. Drugs, 6, 1867 (1997), Slakter, J.S., et al.: Ophthalmology 110, 2372 (2003),

Formula: C₂₃H₃₀O₅

Color and Shape: Beige

Molecular weight: 386.48

Ref: TR-A637640

Hydrocortisone Acetate EP Impurity E

CAS: 7753-60-8

Formula: C₂₃H₃₀O₅

Molecular weight: 386.49

Ref: ST-EA-CP-H9024

Anecortave acetate

Controlled Product

CAS: 7753-60-8

Anecortave acetate is a steroid that has been shown to inhibit angiogenesis and has been approved for the treatment of proliferative diabetic retinopathy. It is a prodrug that undergoes enzymatic cleavage by esterases to release the active form, acetate. This drug is found in high concentrations in the sclera, which could be related to its ability to inhibit angiogenesis. Anecortave acetate inhibits viral replication and inflammation by binding to receptors on cells with these functions. Anecortave acetate also binds to monoclonal antibodies that are used as imaging agents for angiography and fluorescein angiography studies. The anti-angiogenic properties of this drug have been studied using pharmacokinetics studies, animal toxicity studies, and chemical biology approaches.

Formula: C₂₃H₃₀O₅

Purity: Min. 96 Area-%

Color and Shape: White Off-White Powder

Molecular weight: 386.48 g/mol

Ref: 3D-FA17919

Anecortave Acetate

CAS: 7753-60-8

Formula: C₂₃H₃₀O₅

Molecular weight: 386.49

Ref: ST-EA-CP-A257000