CAS 775304-57-9

Ataluren

Description:

Ataluren, with the CAS number 775304-57-9, is a small molecule drug primarily used in the treatment of genetic disorders caused by nonsense mutations, particularly in Duchenne muscular dystrophy (DMD). It functions as a read-through agent, promoting the ribosomal incorporation of amino acids at premature stop codons, thereby allowing for the production of full-length functional proteins. Ataluren is characterized by its ability to selectively enhance the translation of mRNA that contains these mutations, which can lead to improved muscle function in affected individuals. The compound is typically administered orally and has been evaluated for its safety and efficacy in clinical trials. Its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its therapeutic action. While Ataluren has shown promise in clinical settings, its use may be accompanied by side effects, and its effectiveness can vary among patients. Overall, Ataluren represents a significant advancement in the treatment of genetic conditions linked to nonsense mutations, highlighting the potential of targeted therapies in modern medicine.

Formula: C₁₅H₉FN₂O₃

InChI: InChI=1S/C15H9FN2O3/c16-12-7-2-1-6-11(12)14-17-13(18-21-14)9-4-3-5-10(8-9)15(19)20/h1-8H,(H,19,20)

InChI key: InChIKey=OOUGLTULBSNHNF-UHFFFAOYSA-N

SMILES: FC1=C(C2=NC(=NO2)C3=CC(C(O)=O)=CC=C3)C=CC=C1

Synonyms:

• 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoicacid
• Atalure
• Ataluren
• Benzoic acid,3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]-
• Pct 124
• Ptc 124
• Translarna
• 3-[5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acid
• Ataluren(PTC124)

PTC124

CAS: 775304-57-9

Formula: C₁₅H₉FN₂O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 284.2420

Ref: IN-DA005T7O

Ataluren

CAS: 775304-57-9

Formula: C₁₅H₉FN₂O₃

Color and Shape: Off-White Solid

Molecular weight: 284.25

Ref: 4Z-A-152001

Ataluren

CAS: 775304-57-9

Ataluren

Purity: ≥98%

Molecular weight: 284.24g/mol

Ref: 54-BUP15408

3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

CAS: 775304-57-9

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 284.2460021972656

Ref: 10-F093613

Ataluren

CAS: 775304-57-9

Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.

Formula: C₁₅H₉FN₂O₃

Purity: 99.16% - 99.84%

Color and Shape: Solid

Molecular weight: 284.24

Ref: TM-T1805

3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

CAS: 775304-57-9

3-(5-(2-Fluorophenyl)-1,2,4-oxadiazol-3-yl)benzoic acid

Formula: C₁₅H₉FN₂O₃

Purity: 98%

Color and Shape: white powder

Molecular weight: 284.24g/mol

Ref: 54-BI9879

PTC-124

Controlled Product

CAS: 775304-57-9

Applications PTC-124 is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins,
References Yu, H. et al.: Int. J. Mol. Med., 33, 729 (2014); Aditya, S. et al.: J. Biomed. Pharm. Res., 2, 21 (2013);

Formula: C₁₅H₉FN₂O₃

Color and Shape: White To Off-White

Molecular weight: 284.24

Ref: TR-P839830

Ataluren

CAS: 775304-57-9

Ataluren is a drug that was developed to treat Duchenne muscular dystrophy. It is an orally administered small molecule that has been shown to restore the production of a protein called dystrophin, which is missing in people with Duchenne muscular dystrophy. The drug works by binding to the RNA polymerase and terminating transcription of the mutated gene that causes the disease. Ataluren has been studied in clinical trials as an alternative to steroids, which are used to slow or stop muscle deterioration and allow the body's natural healing process to take place. This drug has also been shown to be effective against other mutations, including those associated with cystic fibrosis and Huntington's disease.

Formula: C₁₅H₉FN₂O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 284.24 g/mol

Ref: 3D-FF106142