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CAS 77590-96-6

:

Flordipine

Description:
Flordipine is a calcium channel blocker primarily used in the treatment of hypertension and angina pectoris. It belongs to the dihydropyridine class of calcium antagonists, which work by inhibiting the influx of calcium ions through L-type calcium channels in vascular smooth muscle and cardiac tissue. This action leads to vasodilation, reducing peripheral vascular resistance and lowering blood pressure. Flordipine is characterized by its high selectivity for vascular smooth muscle over cardiac tissue, which minimizes negative effects on heart rate. The compound is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Its chemical structure includes a dihydropyridine ring, which is essential for its pharmacological activity. Flordipine is generally well-tolerated, but like other medications in its class, it may cause side effects such as headache, flushing, and peripheral edema. As with any medication, it is important for patients to consult healthcare professionals for appropriate use and potential interactions with other drugs.
Formula:C26H33F3N2O5
InChI:InChI=1/C26H33F3N2O5/c1-5-35-24(32)21-17(3)31(12-11-30-13-15-34-16-14-30)18(4)22(25(33)36-6-2)23(21)19-9-7-8-10-20(19)26(27,28)29/h7-10,23H,5-6,11-16H2,1-4H3
Synonyms:
  • Flordipino [Spanish]
  • Flordipinum [Latin]
  • Flordipine [USAN:INN]
  • Flordipinum
  • Flordipino
  • RHC 2906
  • diethyl 2,6-dimethyl-1-[2-(morpholin-4-yl)ethyl]-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
  • UNII-Z8UFI7XI7R
  • Diethyl 1,4-dihydro-2,6-dimethyl-1-(2-morpholinoethyl)-4-(alpha,alpha,alpha-trifluoro-o-tolyl)3,5-pyridinedicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-1-(2-(4-morpholinyl)ethyl)-4-(2-(trifluoromethyl)phenyl)-, diethyl ester
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