CAS 7763-65-7

L-Histidyl-L-leucine

Description:

L-Histidyl-L-leucine, with the CAS number 7763-65-7, is a dipeptide composed of the amino acids histidine and leucine. It is characterized by its specific sequence, where histidine is linked to leucine through a peptide bond. This compound is known for its role in biological systems, particularly in protein synthesis and metabolism. L-Histidyl-L-leucine exhibits properties typical of peptides, such as solubility in water and the ability to form hydrogen bonds due to the presence of polar functional groups. It may also exhibit biological activity, potentially influencing various physiological processes. The presence of the imidazole side chain from histidine can contribute to its buffering capacity and interactions with metal ions. Additionally, the hydrophobic nature of leucine can affect the peptide's overall structure and stability in aqueous environments. Overall, L-Histidyl-L-leucine serves as an important model for studying peptide behavior and interactions in biochemical research.

Formula: C₁₂H₂₀N₄O₃

InChI: InChI=1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)/t9-,10-/m0/s1

InChI key: InChIKey=MMFKFJORZBJVNF-UWVGGRQHSA-N

SMILES: C([C@@H](C(N[C@@H](CC(C)C)C(O)=O)=O)N)C1=CN=CN1

Synonyms:

• 28: PN: WO2009143133 PAGE: 61 claimed protein
• 83: PN: EP2161028 PAGE: 10 claimed protein
• <span class="text-smallcaps">L</smallcap>-Histidyl-<smallcap>L</span>-leucine
• <span class="text-smallcaps">L</smallcap>-Leucine, <smallcap>L</span>-histidyl-
• <span class="text-smallcaps">L</smallcap>-Leucine, N-<smallcap>L</span>-histidyl-
• H-His-Leu-OH
• Histidylleucine
• L-histidyl-L-leucine
• Leucine, N-<span class="text-smallcaps">L</smallcap>-histidyl-, <smallcap>L</span>-
• Leucine, N-histidyl-
• N-Histidylleucine
• L-Leucine, N-L-histidyl-
• L-Leucine, L-histidyl-

H-His-Leu-OH

CAS: 7763-65-7

His-Leu, C-terminal dipeptide of angiotensin I is split off by action of angiotensin-converting enzyme (ACE) yielding angiotensin II. See also ACE substrates Z-FHL and HHL. The complex generated from Cu(II), His-Leu and ethylene diamine (or His) hydrolytically cleaves the phosphodiester backbone of DNA.

Formula: C₁₂H₂₀N₄O₃

Purity: > 99%

Color and Shape: White Powder

Molecular weight: 268.32

Ref: 01-4000307

H-His-Leu-OH

CAS: 7763-65-7

Formula: C₁₂H₂₀N₄O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 268.3122

Ref: IN-DA003RA4

His-Leu

CAS: 7763-65-7

His-Leu is a signal peptide that contains the amino acid sequence His-Leu. It is used in a variety of diagnostic tests and has been shown to bind to the p-hydroxybenzoic acid inhibitor binding site on the enzyme histone H1. This peptide has also been shown to inhibit the activity of histone H1 enzymes, which are involved in the regulation of DNA replication and transcription. In addition, His-Leu has been shown to inhibit specific enzymes that regulate human serum albumin synthesis, such as preparative high performance liquid chromatography (Hplc) and terminal residues. His-Leu can be used for diagnosis or as an inhibitor for infectious diseases.

Formula: C₁₂H₂₀N₄O₃

Purity: Min. 95%

Molecular weight: 268.31 g/mol

Ref: 3D-OHL-3065