[131I]-m-Iodobenzylguanidine (IBG) is a radiopharmaceutical compound primarily used in nuclear medicine for diagnostic imaging and therapeutic applications, particularly in the context of neuroendocrine tumors and pheochromocytoma. It is a derivative of guanidine, where the iodine-131 isotope is attached to the m-iodobenzyl group, allowing for targeted uptake in adrenergic tissues. The compound exhibits characteristics typical of radiolabeled agents, including a relatively short half-life due to the radioactive nature of iodine-131, which emits beta particles and gamma radiation. This property makes it useful for both imaging and treatment, as it can help visualize tumors and deliver localized radiation therapy. The compound is typically administered intravenously and is known for its affinity for norepinephrine transporters, facilitating its accumulation in neuroendocrine cells. Safety and efficacy are paramount in its use, necessitating careful handling and adherence to regulatory guidelines due to its radioactive properties. Overall, [131I]-m-Iodobenzylguanidine represents a significant tool in the diagnosis and treatment of specific malignancies.

[131I]-m-Iodobenzylguanidine

77679-27-7: [131I]-m-Iodobenzylguanidine (IBG) is a radiopharmaceutical compound primarily used in nuclear medicine for diagnostic imaging and therapeutic applications, particularly in the context of neuroendocrine tumors and pheochromocytoma. It is a derivative of guanidine, where the iodine-131 isotope is attached to the m-iodobenzyl group, allowing for targeted uptake in adrenergic tissues. The compound exhibits characteristics typical of radiolabeled agents, including a relatively short half-life due to the radioactive nature of iodine-131, which emits beta particles and gamma radiation. This property makes it useful for both imaging and treatment, as it can help visualize tumors and deliver localized radiation therapy. The compound is typically administered intravenously and is known for its affinity for norepinephrine transporters, facilitating its accumulation in neuroendocrine cells. Safety and efficacy are paramount in its use, necessitating careful handling and adherence to regulatory guidelines due to its radioactive properties. Overall, [131I]-m-Iodobenzylguanidine represents a significant tool in the diagnosis and treatment of specific malignancies.

<p>Iobenguane I 131 targets sympathetic tissue and tumors; used in cancer treatment and imaging. MIBG blocks neurons, collects in adrenal medulla.</p>

CAS 77679-27-7

[131I]-m-Iodobenzylguanidine

Iobenguane I 131

Ref: TM-T68714