CAS 77739-21-0

B-neoendorphin

Description:

B-neoendorphin, identified by the CAS number 77739-21-0, is a peptide that belongs to the class of endogenous opioid peptides. It is derived from the pro-opiomelanocortin (POMC) precursor and is known for its role in modulating pain, stress, and emotional responses in the body. This peptide exhibits high affinity for opioid receptors, particularly the mu-opioid receptor, which is involved in pain relief and the regulation of mood. B-neoendorphin is characterized by its specific amino acid sequence, which contributes to its biological activity and receptor binding properties. It is typically found in the central nervous system and has been studied for its potential therapeutic effects in pain management and mood disorders. Additionally, like other opioid peptides, B-neoendorphin may have implications in addiction and tolerance, making it a subject of interest in both pharmacological research and clinical studies. Its stability, solubility, and bioavailability are important factors that influence its physiological effects and potential applications in medicine.

Formula: C₅₄H₇₇N₁₃O₁₂

InChI: InChI=1/C54H77N13O12/c1-32(2)26-41(65-51(76)42(28-33-10-4-3-5-11-33)62-46(71)31-60-45(70)30-61-47(72)38(56)27-34-15-19-36(68)20-16-34)50(75)64-40(13-8-24-59-54(57)58)48(73)63-39(12-6-7-23-55)49(74)66-43(29-35-17-21-37(69)22-18-35)52(77)67-25-9-14-44(67)53(78)79/h3-5,10-11,15-22,32,38-44,68-69H,6-9,12-14,23-31,55-56H2,1-2H3,(H,60,70)(H,61,72)(H,62,71)(H,63,73)(H,64,75)(H,65,76)(H,66,74)(H,78,79)(H4,57,58,59)/t38-,39-,40-,41-,42-,43-,44-/m0/s1

SMILES: CC(C)C[C@@H](C(=N[C@@H](CCCNC(=N)N)C(=N[C@@H](CCCCN)C(=N[C@@H](Cc1ccc(cc1)O)C(=O)N1CCC[C@H]1C(=O)O)O)O)O)N=C([C@H](Cc1ccccc1)N=C(CN=C(CN=C([C@H](Cc1ccc(cc1)O)N)O)O)O)O

Synonyms:

• beta-Neo-endorphin
• Big leu-enkephalin
• alpha-Neoendorphin, 10-de-L-lysine-
• L-tyrosylglycylglycyl-L-phenylalanyl-L-leucyl-N~5~-(diaminomethylidene)-L-ornithyl-L-lysyl-L-tyrosyl-L-proline

β-Neoendorphin

CAS: 77739-21-0

A hypothalamic opioid peptide related to Leu-enkephalin and dynorphin A with potent activity in the guinea-pig ileum assay.

Formula: C₅₄H₇₇N₁₃O₁₂

Purity: 98.5%

Color and Shape: White

Molecular weight: 1100.29

Ref: 01-4006024

Beta-Neo-Endorphin (Porcine)

CAS: 77739-21-0

Beta-Neo-Endorphin is an opioid peptide which binds with high affinity to μ, δ and κ-receptors and has been found to be involved in the modulation of pain, epidermal nerve fiber regulation and skin homeostasis. It is further demonstrated the ability to in human keratinocytes, stimulate wound healing. Beta-neoendorphin is derived from prodynorphin when it is proteolytically cleaved.
This product is available as a 0.5mg vials and is sourced from Porcine.

Formula: C₅₄H₇₇N₁₃O₁₂

Purity: Min. 95%

Molecular weight: 1,100.3 g/mol

Ref: 3D-PEN-4091-V

Beta-Neoendorphin

CAS: 77739-21-0

Beta-neoendorphin is a synthetic substrate that has been shown to be hydrolyzed by proteases. It has been shown to have antinociceptive properties in Sprague-Dawley rats, including inhibition of the production of metalloendopeptidase and neutral ph. Beta-neoendorphin also has a molecular weight of approximately 1250 daltons and has been found to bind to opioid receptors. It is active at neutral ph and its optimum pH is 6.0. This peptide can be used for the treatment of neuropathic pain and also for the prevention of morphine tolerance.

Formula: C₅₄H₇₇N₁₃O₁₂

Purity: Min. 95%

Molecular weight: 1,100.27 g/mol

Ref: 3D-FN109269