CAS 77855-81-3

Milbemycin D

Description:

Milbemycin D is a macrocyclic lactone compound that belongs to the milbemycin class of insecticides and anthelmintics. It is primarily derived from the fermentation of the bacterium *Streptomyces hygroscopicus*. This compound exhibits potent activity against a variety of parasitic organisms, including nematodes and arthropods, making it valuable in veterinary medicine and agriculture. Milbemycin D functions by interfering with the transmission of nerve impulses in parasites, leading to paralysis and death. The substance is characterized by its high lipophilicity, which enhances its ability to penetrate biological membranes. It is typically administered in formulations designed for oral or topical use. Safety profiles indicate that while it is effective against target pests, it has a relatively low toxicity to mammals, making it a preferred choice in many applications. However, like all chemical substances, it should be handled with care, following appropriate safety guidelines to mitigate any potential risks to humans and non-target organisms.

Formula: C₃₃H₄₈O₇

InChI: InChI=1/C33H48O7/c1-19(2)29-22(5)12-13-32(40-29)17-26-16-25(39-32)11-10-21(4)14-20(3)8-7-9-24-18-37-30-28(34)23(6)15-27(31(35)38-26)33(24,30)36/h7-10,15,19-20,22,25-30,34,36H,11-14,16-18H2,1-6H3/b8-7+,21-10+,24-9-/t20-,22-,25+,26-,27-,28+,29+,30+,32+,33+/m0/s1

InChI key: InChIKey=BWCRYQGQPDBOAU-WZBVPYLGSA-N

SMILES: [C@H](C)(C)[C@H]1O[C@@]2(C[C@@]3(C[C@](O2)(C/C=C(\C)/C[C@@H](C)\C=C\C=C/4\[C@@]5(O)[C@](C(=O)O3)(C=C(C)[C@@H](O)[C@]5(OC4)[H])[H])[H])[H])CC[C@@H]1C

Synonyms:

• (5'S,6R,6'R,11R,13R,15S,17aR,20R,20aR,20bS)-20,20b-dihydroxy-5',6,8,19-tetramethyl-6'-(1-methylethyl)-3',4',5',6,6',7,10,11,14,15,17a,20,20a,20b-tetradecahydro-2H,17H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-17-one
• (6R,25R)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)milbemycin B
• Antibiotic B 41D
• Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)-, (6R,25R)-
• Milbemycin D
• Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2′-[2H]pyran], milbemycin B deriv.

Milbemycin D

Controlled Product

CAS: 77855-81-3

Impurity Milbemycin EP Impurity C
Stability Hygroscopic
Applications Milbemycin D (Milbemycin EP Impurity C) is a macrocyclic lactones that can be used as a nematocide and insecticide.
References Arena, J. P., et al.: J. Parasitol 81, 286 (1995); Takiguchi, Y., et al.: J. Antibiot 36, 502 (1983)

Formula: C₃₃H₄₈O₇

Color and Shape: Neat

Molecular weight: 556.73

Ref: TR-M344290

Milbemycin D (~90%)

Controlled Product

CAS: 77855-81-3

Applications Milbemycin D (~90% purity) is a macrocyclic lactones that can be used as a nematocide and insecticide.
References Arena, J. P., et al.: J. Parasitol 81, 286 (1995); Takiguchi, Y., et al.: J. Antibiot 36, 502 (1983)

Formula: C₃₃H₄₈O₇

Purity: ~90%

Color and Shape: Neat

Molecular weight: 556.73

Ref: TR-M344305

Milbemycin EP Impurity C

CAS: 77855-81-3

Formula: C₃₃H₄₈O₇

Molecular weight: 556.74

Ref: ST-EA-CP-M95003

Milbemycin D

CAS: 77855-81-3

Formula: C₃₃H₄₈O₇

Molecular weight: 556.74

Ref: 4Z-M-663